Evidence map›Paper›PMID 26382947›Full record

SynthesisPloS one2015

Association between Air Pollutants and Asthma Emergency Room Visits and Hospital Admissions in Time Series Studies: A Systematic Review and Meta-Analysis.

Xue-yan Zheng, Hong Ding, Li-na Jiang, Shao-wei Chen, Jin-ping Zheng, Min Qiu, Ying-xue Zhou, Qing Chen, Wei-jie Guan

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 193 papers, 17 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
193citing papers in PubMed, 17 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

193 citing papers in PubMed, 17 syntheses or guidelines pooled it.

  1. Pooled it
  2. Air pollution and hospitalization risk in infants with bronchiolitis: A systematic review and meta-analysis.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
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  7. Cytogenetic Effects in Children Exposed to Air Pollutants: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
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  10. Environmental and Occupational Short-Term Exposure to Airborne Particles and FEVInternational journal of environmental research and public health · 2021
    Pooled it
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  12. Fibrotic interstitial lung diseases and air pollution: a systematic literature review.European respiratory review : an official journal of the European Respiratory Society · 2020
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133 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xue-yan ZhengDepartment of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangdong, China.
Hong DingDepartment of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangdong, China.
Li-na JiangDepartment of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangdong, China.
Shao-wei ChenDepartment of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangdong, China.
Jin-ping ZhengState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.
Min QiuDepartment of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangdong, China.
Ying-xue ZhouDepartment of Biostatistics, School of Public Health and Tropical Medicine, Southern Medical University, Guangdong, China.
Qing ChenDepartment of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangdong, China.
Wei-jie GuanState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAir pollution constitutes a significant stimulus of asthma exacerbations; however, the impacts of exposure to major air pollutants on asthma-related hospital admissions and emergency room visits (ERVs) have not been fully determined.

objectiveWe sought to quantify the associations between short-term exposure to air pollutants [ozone (O3), carbon monoxide (CO), nitrogen dioxide (NO2), sulfur dioxide (SO2), and particulate matter ≤10 μm (PM10) and PM2.5] and the asthma-related emergency room visits (ERV) and hospitalizations.

methodsSystematic computerized searches without language limitation were performed. Pooled relative risks (RRs) and 95% confidence intervals (95%CIs) were estimated using the random-effect models. Sensitivity analyses and subgroup analyses were also performed.

resultsAfter screening of 246 studies, 87 were included in our analyses. Air pollutants were associated with significantly increased risks of asthma ERVs and hospitalizations [O3: RR(95%CI), 1.009 (1.006, 1.011); I2 = 87.8%, population-attributable fraction (PAF) (95%CI): 0.8 (0.6, 1.1); CO: RR(95%CI), 1.045 (1.029, 1.061); I2 = 85.7%, PAF (95%CI): 4.3 (2.8, 5.7); NO2: RR(95%CI), 1.018 (1.014, 1.022); I2 = 87.6%, PAF (95%CI): 1.8 (1.4, 2.2); SO2: RR(95%CI), 1.011 (1.007, 1.015); I2 = 77.1%, PAF (95%CI): 1.1 (0.7, 1.5); PM10: RR(95%CI), 1.010 (1.008, 1.013); I2 = 69.1%, PAF (95%CI): 1.1 (0.8, 1.3); PM2.5: RR(95%CI), 1.023 (1.015, 1.031); I2 = 82.8%, PAF (95%CI): 2.3 (1.5, 3.1)]. Sensitivity analyses yielded compatible findings as compared with the overall analyses without publication bias. Stronger associations were found in hospitalized males, children and elderly patients in warm seasons with lag of 2 days or greater.

conclusionShort-term exposures to air pollutants account for increased risks of asthma-related ERVs and hospitalizations that constitute a considerable healthcare utilization and socioeconomic burden.

Indexed as

AgedAir PollutantsAir PollutionAmbulatory CareAsthmaChildEmergency Service, HospitalEnvironmental ExposureHumansMaleParticulate MatterPatient AdmissionSeasonsTime FactorsAir PollutantsParticulate Matter

Identifiers

PMID26382947
PMCPMC4575194

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.