Trial reportActa ophthalmologica2015
Visual impairment and vision-related quality of life in the Early Manifest Glaucoma Trial after 20 years of follow-up.
Trial report in Acta ophthalmologica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06604104 (Seeing Through Their Eyes - Towards Defining Visual Frailty in Ageing), which is not on this map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Seeing Through Their Eyes - Towards Defining Visual Frailty in Ageing
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Fifteen-Month Outcomes of Preservative-Free Latanoprost Cationic Emulsion in Open-Angle Glaucoma and Ocular Hypertension: Phase III Open-Label Extension of a Randomized Trial.Clinical ophthalmology (Auckland, N.Z.) · 2025Trial
- Visual field loss and vision-related quality of life in the Italian Primary Open Angle Glaucoma Study.Scientific reports · 2018Trial
- Childhood visual impairment and health-related quality of life in Ghana: evidence from a cross-sectional study.Health and quality of life outcomes · 2026Article
- Threat to fixation and vision-related quality of life in patients with open-angle glaucoma.Acta ophthalmologica · 2026Article
- A retrospective evaluation of the clinical monitoring period prior to referral for glaucoma surgery with the emphasis on visual field test results.BMC ophthalmology · 2025Observational
- Risk factors associated with self-rated health among elderly females with different visual abilities in Chinese urban areas: a population-based study.BMC public health · 2024Article
- Mapping vision loss of patients in a glaucoma backlog following the COVID-19 pandemic: a real-world analysis using the Glauc-Strat-Fast risk stratification tool.Eye (London, England) · 2024Article
- Assessment of quality of life in glaucoma patients in a tertiary care center in Eastern India.Indian journal of ophthalmology · 2023Article
- Factors Associated with Visual Acuity in Advanced Glaucoma.Journal of clinical medicine · 2023Article
- Vision-related quality of life amongst patients with low vision and blindness in a resource-limited country.International ophthalmology · 2023Article
- Threat to fixation and vision-related quality of life in early open-angle glaucoma - results from the Glaucoma Intensive Treatment Study.Acta ophthalmologica · 2023Article
- Glaucoma Medication and Quality of Life after Phacoemulsification Combined with a Xen Gel Stent.Journal of clinical medicine · 2022Article
- What do patients with glaucoma see: a novel iPad app to improve glaucoma patient awareness of visual field loss.The British journal of ophthalmology · 2022Article
- Vision-related quality-of-life in Jamaican glaucoma patients at Kingston Public Hospital.International journal of ophthalmology · 2022Article
- A Review of Studies of the Association of Vision-Related Quality of Life with Measures of Visual Function and Structure in Patients with Glaucoma in the United States.Ophthalmic epidemiology · 2021Review
- The effects of age-related macular degeneration on quality of life in a Brazilian population.International journal of retina and vitreous · 2021Article
- Article
- Predicting Adherence With the Glaucoma Treatment Compliance Assessment Tool.Journal of glaucoma · 2020Article
- The Only Eye Study (OnES): a qualitative study of surgeon experiences of only eye surgery and recommendations for patient safety.BMJ open · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
purposeTo determine the association between vision-related quality of life (VRQOL) and levels of visual function loss in the Early Manifest Glaucoma Trial (EMGT).
methodsTwo hundred and fifty-five patients were included in the EMGT between 1993 and 1997 and followed regularly by ophthalmic examinations. A Swedish translation of the National Eye Institute Visual Function Questionnaire 25 (NEI VFQ-25) was self-administered at several follow-up visits until 2014. We analysed the association between Rasch-calibrated NEI VFQ-25 scores and visual function in the best eye at the final follow-up visit.
resultsNinety-one per cent (233/255) of all participants completed the NEI VFQ-25 at least once. In univariate logistic regression analysis, NEI VFQ-25 scores were modestly associated with visual acuity (VA) (r(2) = 0.330, p < 0.001), visual field index (VFI) (r(2) = 0.200, p < 0.001) and perimetric mean deviation (MD) (r(2) = 0.193, p < 0.001). In multivariate analysis, VA and VFI together accounted for approximately 40% (r(2) = 0.380) of the NEI VFQ-25 scores. NEI VFQ-25 scores were significantly higher for patients with no visual impairment (mean 73 ± 22) than for visually impaired patients (mean 31 ± 15, p < 0.001). VFI worse than 50% or MD worse than -18 dB was significantly associated with low VRQOL scores (p < 0.001).
conclusionsOur results support the widespread, albeit arbitrary, use of a better-eye visual field of <50% as an important threshold for a significant reduction in VRQOL.
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