ArticleThe journal of headache and pain2015
Clinical and Demographical Characteristics of Patients with Medication Overuse Headache in Argentina and Chile: Analysis of the Latin American Section of COMOESTAS Project.
Article in The journal of headache and pain, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07568496 (Greater Occipital Nerve Block for Migraine With Medication Overuse Headache), which is not on this map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Greater Occipital Nerve Block for Migraine With Medication Overuse Headache
Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- FRAMES protocol versus simple advice for medication-overuse headache: a prospective, randomized, controlled clinical trial.Acta neurologica Belgica · 2021Trial
- Medication overuse headache from a tertiary headache center in Egypt: real-world insights.The journal of headache and pain · 2026Article
- Ergotamine, triptans, and the global challenge of medication-overuse headache: a call to action from Asia-Oceania.The journal of headache and pain · 2025Article
- Ergotamine and triptans induced medication-overuse headache: a real-world population-based comparative study from the Northern Thai headache registry.The journal of headache and pain · 2025Article
- Unveiling the Public Economic Burden of Migraine in Argentina.Journal of health economics and outcomes research · 2025Article
- Medication-Overuse Headache: Update on Management.Life (Basel, Switzerland) · 2024Review
- Association between Body Mass Index and Medication-Overuse Headache among Individuals with Migraine: A Cross-Sectional Study.Obesity facts · 2024Article
- Medication overuse headache: a review of current evidence and management strategies.Frontiers in pain research (Lausanne, Switzerland) · 2023Review
- High rates of (treated) hypothyroidism among chronic migraine patients consulting a specialized headache clinic: are we missing something?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Insomnia in neurological diseases.Neurological research and practice · 2021Article
- Evaluation of LY573144 (lasmiditan) in a preclinical model of medication overuse headache.Cephalalgia : an international journal of headache · 2020Article
- Field testing of the ICHD-3β and expert opinion criteria for chronic migraine.The journal of headache and pain · 2016Article
- Medication-overuse headache: risk factors, pathophysiology and management.Nature reviews. Neurology · 2016Review
- Medication-overuse headache: a perspective review.Therapeutic advances in drug safety · 2016Review
- Chronic Daily Headache and Medication Overuse Headache in First-Visit Headache Patients in Korea: A Multicenter Clinic-Based Study.Journal of clinical neurology (Seoul, Korea) · 2016Article
- Medication overuse headache in Europe and Latin America: general demographic and clinical characteristics, referral pathways and national distribution of painkillers in a descriptive, multinational, multicenter study.The journal of headache and pain · 2015Observational
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundData on the characteristics of Medication Overuse Headache (MOH) in Latin American (LA) are scarce. Here we report the demographic and clinical features of the MOH patients from Argentina and Chile enrolled in the multinational COMOESTAS project in the period 2008-2010.
methodsThe LA population was formed by 240 MOH subjects, 110 from Chile and 130 from Argentina, consecutively attending the local headache centres. In each centre, specifically trained neurologist interviewed and confirmed the diagnosis according to the ICHD-II criteria. A detailed history was collected on an electronic patient record form.
resultsThe mean patient age was 38.6 years, with a female/male ratio of 8:2. The mean time since onset of the primary headache was 21 years, whereas duration of MOH was 3.9 years. The primary headache was migraine without aura in 77.5 % and migraine with aura in 18.8 %. Forty two % of the patients self-reported emotional stress associated with the chronification of headache; 43.8 % reported insomnia. The most overused medications were acute drug combinations containing ergotamine (70 %), NSAIDs (33.8 %) and triptans (5.4 %).
conclusionThough little described, MOH is present also in LA, where it affects mostly women, in the most active decades of life. Some differences emerge as regards the demographic and clinical characteristics of MOH in this population as compared to Europe or Northern America. What seems more worrying about MOH in Argentina and Chile is that most patients overuse ergotamine, a drug that may cause serious adverse events when used chronically. These findings once more underscore the importance of properly diagnose and treat MOH.
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