Trial reportSocial cognitive and affective neuroscience2016
Effects of intranasal oxytocin on amygdala reactivity to emotional faces in recently trauma-exposed individuals.
Trial report in Social cognitive and affective neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03211013 (Placebo-Controlled Study of the Effects of Oxytocin on Attentional Bias and Startle in PTSD), which is not on this map. Cited by 32 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Placebo-Controlled Study of the Effects of Oxytocin on Attentional Bias and Startle in PTSD
Who cites it
32 citing papers in PubMed, 5 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Exploring the efficacy of intranasal oxytocin (OXT) for anxiety and stress-related disorders through functional magnetic resonance imaging (fMRI) study: a systematic review.BMC pharmacology & toxicology · 2025Pooled it
- Early pharmacological interventions for prevention of post-traumatic stress disorder (PTSD) in individuals experiencing acute traumatic stress symptoms.The Cochrane database of systematic reviews · 2024Pooled it
- Functional brain changes after alternative pharmacological interventions in posttraumatic stress disorder: A systematic review of clinical trials.Brain and behavior · 2023Pooled it
- Early pharmacological interventions for universal prevention of post-traumatic stress disorder (PTSD).The Cochrane database of systematic reviews · 2022Pooled it
- Neural substrates underlying the effects of oxytocin: a quantitative meta-analysis of pharmaco-imaging studies.Social cognitive and affective neuroscience · 2017Pooled it
- Post-encoding administration of oxytocin selectively enhances memory consolidation of male faces in females.Proceedings of the National Academy of Sciences of the United States of America · 2026Trial
- Age-dependent effects of oxytocin in brain regions enriched with oxytocin receptors.Psychoneuroendocrinology · 2024Trial
- Preliminary data on oxytocin modulation of neural reactivity in women to emotional stimuli of children depending on childhood emotional neglect.Developmental psychobiology · 2023Trial
- Oxytocin treatment attenuates amygdala activity in autism: a treatment-mechanism study with long-term follow-up.Translational psychiatry · 2020Trial
- Oxytocin induces long-lasting adaptations within amygdala circuitry in autism: a treatment-mechanism study with randomized placebo-controlled design.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Intranasal Oxytocin Affects Amygdala Functional Connectivity after Trauma Script-Driven Imagery in Distressed Recently Trauma-Exposed Individuals.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- Circuit logic of oxytocin and vasopressin complementary actions.Frontiers in neuroscience · 2026Review
- Salivary oxytocin and amygdalar alterations in functional neurological disorders.Brain communications · 2025Article
- Oxytocin enhances the triangular association among behavior, resting-state, and task-state functional connectivity.Human brain mapping · 2023Article
- Review
- Oxytocin enhances basolateral amygdala activation and functional connectivity while processing emotional faces: preliminary findings in autistic vs non-autistic women.Social cognitive and affective neuroscience · 2022Article
- Neural correlates of treatment effect and prediction of treatment outcome in patients with PTSD and comorbid personality disorder: study design.Borderline personality disorder and emotion dysregulation · 2021Article
- Decreased Plasma Oxytocin Levels in Patients With PTSD.Frontiers in psychology · 2021Article
- Advances in the field of intranasal oxytocin research: lessons learned and future directions for clinical research.Molecular psychiatry · 2021Review
- The oxytocinergic system in PTSD following traumatic childbirth: endogenous and exogenous oxytocin in the peripartum period.Archives of women's mental health · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledThere is a need for effective, early post-trauma preventive interventions for post-traumatic stress disorder (PTSD). Attenuating amygdala hyperreactivity early post-trauma, a likely PTSD vulnerability factor, may decrease PTSD risk. Since oxytocin modulates amygdala reactivity to emotional stimuli, oxytocin administration early post-trauma may be a promising candidate for PTSD prevention. In a randomized double-blind placebo-controlled fMRI study, we investigated effects of a single intranasal oxytocin administration (40 IU) on amygdala reactivity to happy, neutral and fearful faces in 41 recently trauma-exposed men and women showing moderate to high distress after initial post-trauma screening. We explored treatment interactions with sex. Participants were scanned within 11 days post-trauma. Compared with placebo, oxytocin significantly increased right amygdala reactivity to fearful faces. There was a significant treatment by sex interaction on amygdala reactivity to neutral faces, with women showing increased left amygdala reactivity after oxytocin. These findings indicate that a single oxytocin administration may enhance fearful faces processing in recently trauma-exposed individuals and neutral faces processing in recently trauma-exposed women. These observations may be explained by oxytocin-induced increased salience processing. Clinical implications of these findings for PTSD prevention should be further investigated. TRIAL REGISTER: Netherlands Trial Registry; Boosting Oxytocin after trauma: Neurobiology and the Development of Stress-related psychopathology (BONDS); NTR3190; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC = 3190.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.