ArticleThe Journal of pediatrics2015
Impact of Fetal-Neonatal Iron Deficiency on Recognition Memory at 2 Months of Age.
Article in The Journal of pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 4 syntheses or guidelines pooled it, 118 citations in OpenAlex.
- Pooled it
- The Effects of Prenatal Iron Supplementation on Offspring Neurodevelopment in Upper Middle- or High-Income Countries: A Systematic Review.Nutrients · 2024Pooled it
- The Prevalence of Nutritional Anaemia in Brazilian Pregnant Women: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2023Pooled it
- The Role of Iron in Brain Development: A Systematic Review.Nutrients · 2020Pooled it
- Enteral iron dose effect on iron storage, intestinal barrier, and gut microbiome in preterm infants: a randomized clinical trial.The American journal of clinical nutrition · 2026Trial
- Efficacy of Single-Dose Intravenous Ferric Derisomaltose for Iron Deficiency Anemia in Pregnancy.American journal of hematology · 2026Trial
- The impact of different doses of oral iron supplementation during pregnancy: a pilot randomized trial.Blood advances · 2024Trial
- Enteral Iron Supplementation in Infants Born Extremely Preterm and its Positive Correlation with Neurodevelopment; Post Hoc Analysis of the Preterm Erythropoietin Neuroprotection Trial Randomized Controlled Trial.The Journal of pediatrics · 2021Trial
- Effect of High-Dose Erythropoietin on Blood Transfusions in Extremely Low Gestational Age Neonates: Post Hoc Analysis of a Randomized Clinical Trial.JAMA pediatrics · 2020Trial
- Iron Supplementation and Neurodevelopmental Outcomes in Infancy and Early Childhood: A Review.Children (Basel, Switzerland) · 2026Review
- Effects of implementing a standardized protocol for identifying and treating iron-deficiency anemia in pregnancy.Pregnancy (Hoboken, N.J.) · 2025Article
- Maternal Prenatal Psychological Stress and Iron Levels in the Fetal Brain.Developmental psychobiology · 2025Article
- Iron mother- protocol for a randomised controlled trial of daily versus alternate day ferrous fumarate for the treatment of iron deficiency anaemia in pregnancy.Contemporary clinical trials communications · 2025Article
- Iron optimisation in pregnancy: a Haematology in Obstetric and Women's Health Collaborative consensus statement.Internal medicine journal · 2025Article
- Whole Brain MRI Assessment of Age and Sex-Related R2* Changes in the Human Fetal Brain.Human brain mapping · 2025Article
- Effects of prenatal iron deficiency on neurological development and related disorders in offspring.Frontiers in nutrition · 2025Review
- Early life stress and iron metabolism in developmental psychoneuroimmunology.Brain, behavior, & immunity - health · 2024Article
- Biomarkers of Brain Dysfunction in Perinatal Iron Deficiency.Nutrients · 2024Review
- Early cognitive assessment in premature infants: the discriminatory value of eye-tracking vs. Bayley Scales.Frontiers in psychology · 2024Article
- Identifying and treating iron deficiency anemia in pregnancy.Hematology. American Society of Hematology. Education Program · 2023Article
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveTo assess the effects of fetal-neonatal iron deficiency on recognition memory in early infancy. Perinatal iron deficiency delays or disrupts hippocampal development in animal models and thus may impair related neural functions in human infants, such as recognition memory. STUDY
designEvent-related potentials were used in an auditory recognition memory task to compare 2-month-old Chinese infants with iron sufficiency or deficiency at birth. Fetal-neonatal iron deficiency was defined 2 ways: high zinc protoporphyrin/heme ratio (ZPP/H > 118 μmol/mol) or low serum ferritin (<75 μg/L) in cord blood. Late slow wave was used to measure infant recognition of mother's voice.
resultsEvent related potentials patterns differed significantly for fetal-neonatal iron deficiency as defined by high cord ZPP/H but not low ferritin. Comparing 35 infants with iron deficiency (ZPP/H > 118 μmol/mol) to 92 with lower ZPP/H (iron-sufficient), only infants with iron sufficiency showed larger late slow wave amplitude for stranger's voice than mother's voice in frontal-central and parietal-occipital locations, indicating the recognition of mother's voice.
conclusionsInfants with iron sufficiency showed electrophysiological evidence of recognizing their mother's voice, whereas infants with fetal-neonatal iron deficiency did not. Their poorer auditory recognition memory at 2 months of age is consistent with effects of fetal-neonatal iron deficiency on the developing hippocampus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.