Evidence map›Paper›PMID 26382176›Full record

ArticleStroke2015

Trail Making Test Elucidates Neural Substrates of Specific Poststroke Executive Dysfunctions.

Ryan T Muir, Benjamin Lam, Kie Honjo, Robin D Harry, Alicia A McNeely, Fu-Qiang Gao, Joel Ramirez, Christopher J M Scott, Anoop Ganda, Jiali Zhao and 11 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 76 citations in OpenAlex.

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  20. The role of left insula in executive set-switching: Lesion evidence from an acute stroke cohort.Cortex; a journal devoted to the study of the nervous system and behavior · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 8 institutions in 3 countries.

Ryan T MuirFrom the L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.E.B.), Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., S.E.B.), Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.J.G., E.G., D.T.S., S.E.B.), Department of Medicine, Division of Neurology (R.T.M., B.L., K.H., R.D.H., A.A.M., F.Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., N.J.L , D.T.S., S.E.B.), Department of Medical Biophysics (S.J.G.), Rotman Research Institute, Baycrest (D.T.S., S.E.B.), and Department of Research Design and Biostatistics, Sunnybrook Health Sciences Centre (A.K.), University of Toronto, Toronto, ON, Canada; Departments of Radiology, Neurosurgery, and Bioengineering (X.J.Z.), and Department of Clinical Neuropsychology (N.R., D.L.N.), College of Medicine at Chicago, University of Illinois; Hauenstein Neuroscience Center, Saint Mary's Health Care, Grand Rapids, MI (N.R., D.L.N.); Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada (N.J.L.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, South Korea (B.-C.L., Y.K.); Department of Psychology, Hallym University, Chuncheon, South Korea (Y.K.); and Heart and Stroke Foundation Canadian Partnership for Stroke Recovery (K.H., S.E.B.).
Benjamin LamFrom the L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.E.B.), Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., S.E.B.), Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.J.G., E.G., D.T.S., S.E.B.), Department of Medicine, Division of Neurology (R.T.M., B.L., K.H., R.D.H., A.A.M., F.Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., N.J.L , D.T.S., S.E.B.), Department of Medical Biophysics (S.J.G.), Rotman Research Institute, Baycrest (D.T.S., S.E.B.), and Department of Research Design and Biostatistics, Sunnybrook Health Sciences Centre (A.K.), University of Toronto, Toronto, ON, Canada; Departments of Radiology, Neurosurgery, and Bioengineering (X.J.Z.), and Department of Clinical Neuropsychology (N.R., D.L.N.), College of Medicine at Chicago, University of Illinois; Hauenstein Neuroscience Center, Saint Mary's Health Care, Grand Rapids, MI (N.R., D.L.N.); Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada (N.J.L.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, South Korea (B.-C.L., Y.K.); Department of Psychology, Hallym University, Chuncheon, South Korea (Y.K.); and Heart and Stroke Foundation Canadian Partnership for Stroke Recovery (K.H., S.E.B.).
Kie HonjoFrom the L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.E.B.), Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., S.E.B.), Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.J.G., E.G., D.T.S., S.E.B.), Department of Medicine, Division of Neurology (R.T.M., B.L., K.H., R.D.H., A.A.M., F.Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., N.J.L , D.T.S., S.E.B.), Department of Medical Biophysics (S.J.G.), Rotman Research Institute, Baycrest (D.T.S., S.E.B.), and Department of Research Design and Biostatistics, Sunnybrook Health Sciences Centre (A.K.), University of Toronto, Toronto, ON, Canada; Departments of Radiology, Neurosurgery, and Bioengineering (X.J.Z.), and Department of Clinical Neuropsychology (N.R., D.L.N.), College of Medicine at Chicago, University of Illinois; Hauenstein Neuroscience Center, Saint Mary's Health Care, Grand Rapids, MI (N.R., D.L.N.); Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada (N.J.L.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, South Korea (B.-C.L., Y.K.); Department of Psychology, Hallym University, Chuncheon, South Korea (Y.K.); and Heart and Stroke Foundation Canadian Partnership for Stroke Recovery (K.H., S.E.B.).
Robin D HarryFrom the L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.E.B.), Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., S.E.B.), Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.J.G., E.G., D.T.S., S.E.B.), Department of Medicine, Division of Neurology (R.T.M., B.L., K.H., R.D.H., A.A.M., F.Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., N.J.L , D.T.S., S.E.B.), Department of Medical Biophysics (S.J.G.), Rotman Research Institute, Baycrest (D.T.S., S.E.B.), and Department of Research Design and Biostatistics, Sunnybrook Health Sciences Centre (A.K.), University of Toronto, Toronto, ON, Canada; Departments of Radiology, Neurosurgery, and Bioengineering (X.J.Z.), and Department of Clinical Neuropsychology (N.R., D.L.N.), College of Medicine at Chicago, University of Illinois; Hauenstein Neuroscience Center, Saint Mary's Health Care, Grand Rapids, MI (N.R., D.L.N.); Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada (N.J.L.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, South Korea (B.-C.L., Y.K.); Department of Psychology, Hallym University, Chuncheon, South Korea (Y.K.); and Heart and Stroke Foundation Canadian Partnership for Stroke Recovery (K.H., S.E.B.).
Alicia A McNeelyFrom the L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.E.B.), Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., S.E.B.), Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.J.G., E.G., D.T.S., S.E.B.), Department of Medicine, Division of Neurology (R.T.M., B.L., K.H., R.D.H., A.A.M., F.Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., N.J.L , D.T.S., S.E.B.), Department of Medical Biophysics (S.J.G.), Rotman Research Institute, Baycrest (D.T.S., S.E.B.), and Department of Research Design and Biostatistics, Sunnybrook Health Sciences Centre (A.K.), University of Toronto, Toronto, ON, Canada; Departments of Radiology, Neurosurgery, and Bioengineering (X.J.Z.), and Department of Clinical Neuropsychology (N.R., D.L.N.), College of Medicine at Chicago, University of Illinois; Hauenstein Neuroscience Center, Saint Mary's Health Care, Grand Rapids, MI (N.R., D.L.N.); Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada (N.J.L.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, South Korea (B.-C.L., Y.K.); Department of Psychology, Hallym University, Chuncheon, South Korea (Y.K.); and Heart and Stroke Foundation Canadian Partnership for Stroke Recovery (K.H., S.E.B.).
Fu-Qiang GaoFrom the L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.E.B.), Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., S.E.B.), Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.J.G., E.G., D.T.S., S.E.B.), Department of Medicine, Division of Neurology (R.T.M., B.L., K.H., R.D.H., A.A.M., F.Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., N.J.L , D.T.S., S.E.B.), Department of Medical Biophysics (S.J.G.), Rotman Research Institute, Baycrest (D.T.S., S.E.B.), and Department of Research Design and Biostatistics, Sunnybrook Health Sciences Centre (A.K.), University of Toronto, Toronto, ON, Canada; Departments of Radiology, Neurosurgery, and Bioengineering (X.J.Z.), and Department of Clinical Neuropsychology (N.R., D.L.N.), College of Medicine at Chicago, University of Illinois; Hauenstein Neuroscience Center, Saint Mary's Health Care, Grand Rapids, MI (N.R., D.L.N.); Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada (N.J.L.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, South Korea (B.-C.L., Y.K.); Department of Psychology, Hallym University, Chuncheon, South Korea (Y.K.); and Heart and Stroke Foundation Canadian Partnership for Stroke Recovery (K.H., S.E.B.).
Joel RamirezFrom the L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.E.B.), Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., S.E.B.), Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.J.G., E.G., D.T.S., S.E.B.), Department of Medicine, Division of Neurology (R.T.M., B.L., K.H., R.D.H., A.A.M., F.Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., N.J.L , D.T.S., S.E.B.), Department of Medical Biophysics (S.J.G.), Rotman Research Institute, Baycrest (D.T.S., S.E.B.), and Department of Research Design and Biostatistics, Sunnybrook Health Sciences Centre (A.K.), University of Toronto, Toronto, ON, Canada; Departments of Radiology, Neurosurgery, and Bioengineering (X.J.Z.), and Department of Clinical Neuropsychology (N.R., D.L.N.), College of Medicine at Chicago, University of Illinois; Hauenstein Neuroscience Center, Saint Mary's Health Care, Grand Rapids, MI (N.R., D.L.N.); Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada (N.J.L.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, South Korea (B.-C.L., Y.K.); Department of Psychology, Hallym University, Chuncheon, South Korea (Y.K.); and Heart and Stroke Foundation Canadian Partnership for Stroke Recovery (K.H., S.E.B.).
Christopher J M ScottFrom the L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.E.B.), Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., S.E.B.), Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.J.G., E.G., D.T.S., S.E.B.), Department of Medicine, Division of Neurology (R.T.M., B.L., K.H., R.D.H., A.A.M., F.Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., N.J.L , D.T.S., S.E.B.), Department of Medical Biophysics (S.J.G.), Rotman Research Institute, Baycrest (D.T.S., S.E.B.), and Department of Research Design and Biostatistics, Sunnybrook Health Sciences Centre (A.K.), University of Toronto, Toronto, ON, Canada; Departments of Radiology, Neurosurgery, and Bioengineering (X.J.Z.), and Department of Clinical Neuropsychology (N.R., D.L.N.), College of Medicine at Chicago, University of Illinois; Hauenstein Neuroscience Center, Saint Mary's Health Care, Grand Rapids, MI (N.R., D.L.N.); Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada (N.J.L.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, South Korea (B.-C.L., Y.K.); Department of Psychology, Hallym University, Chuncheon, South Korea (Y.K.); and Heart and Stroke Foundation Canadian Partnership for Stroke Recovery (K.H., S.E.B.).
Anoop GandaFrom the L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.E.B.), Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., S.E.B.), Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.J.G., E.G., D.T.S., S.E.B.), Department of Medicine, Division of Neurology (R.T.M., B.L., K.H., R.D.H., A.A.M., F.Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., N.J.L , D.T.S., S.E.B.), Department of Medical Biophysics (S.J.G.), Rotman Research Institute, Baycrest (D.T.S., S.E.B.), and Department of Research Design and Biostatistics, Sunnybrook Health Sciences Centre (A.K.), University of Toronto, Toronto, ON, Canada; Departments of Radiology, Neurosurgery, and Bioengineering (X.J.Z.), and Department of Clinical Neuropsychology (N.R., D.L.N.), College of Medicine at Chicago, University of Illinois; Hauenstein Neuroscience Center, Saint Mary's Health Care, Grand Rapids, MI (N.R., D.L.N.); Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada (N.J.L.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, South Korea (B.-C.L., Y.K.); Department of Psychology, Hallym University, Chuncheon, South Korea (Y.K.); and Heart and Stroke Foundation Canadian Partnership for Stroke Recovery (K.H., S.E.B.).
Jiali ZhaoFrom the L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.E.B.), Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., S.E.B.), Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.J.G., E.G., D.T.S., S.E.B.), Department of Medicine, Division of Neurology (R.T.M., B.L., K.H., R.D.H., A.A.M., F.Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., N.J.L , D.T.S., S.E.B.), Department of Medical Biophysics (S.J.G.), Rotman Research Institute, Baycrest (D.T.S., S.E.B.), and Department of Research Design and Biostatistics, Sunnybrook Health Sciences Centre (A.K.), University of Toronto, Toronto, ON, Canada; Departments of Radiology, Neurosurgery, and Bioengineering (X.J.Z.), and Department of Clinical Neuropsychology (N.R., D.L.N.), College of Medicine at Chicago, University of Illinois; Hauenstein Neuroscience Center, Saint Mary's Health Care, Grand Rapids, MI (N.R., D.L.N.); Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada (N.J.L.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, South Korea (B.-C.L., Y.K.); Department of Psychology, Hallym University, Chuncheon, South Korea (Y.K.); and Heart and Stroke Foundation Canadian Partnership for Stroke Recovery (K.H., S.E.B.).
X Joe ZhouFrom the L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.E.B.), Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., S.E.B.), Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.J.G., E.G., D.T.S., S.E.B.), Department of Medicine, Division of Neurology (R.T.M., B.L., K.H., R.D.H., A.A.M., F.Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., N.J.L , D.T.S., S.E.B.), Department of Medical Biophysics (S.J.G.), Rotman Research Institute, Baycrest (D.T.S., S.E.B.), and Department of Research Design and Biostatistics, Sunnybrook Health Sciences Centre (A.K.), University of Toronto, Toronto, ON, Canada; Departments of Radiology, Neurosurgery, and Bioengineering (X.J.Z.), and Department of Clinical Neuropsychology (N.R., D.L.N.), College of Medicine at Chicago, University of Illinois; Hauenstein Neuroscience Center, Saint Mary's Health Care, Grand Rapids, MI (N.R., D.L.N.); Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada (N.J.L.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, South Korea (B.-C.L., Y.K.); Department of Psychology, Hallym University, Chuncheon, South Korea (Y.K.); and Heart and Stroke Foundation Canadian Partnership for Stroke Recovery (K.H., S.E.B.).
Simon J GrahamFrom the L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.E.B.), Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., S.E.B.), Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.J.G., E.G., D.T.S., S.E.B.), Department of Medicine, Division of Neurology (R.T.M., B.L., K.H., R.D.H., A.A.M., F.Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., N.J.L , D.T.S., S.E.B.), Department of Medical Biophysics (S.J.G.), Rotman Research Institute, Baycrest (D.T.S., S.E.B.), and Department of Research Design and Biostatistics, Sunnybrook Health Sciences Centre (A.K.), University of Toronto, Toronto, ON, Canada; Departments of Radiology, Neurosurgery, and Bioengineering (X.J.Z.), and Department of Clinical Neuropsychology (N.R., D.L.N.), College of Medicine at Chicago, University of Illinois; Hauenstein Neuroscience Center, Saint Mary's Health Care, Grand Rapids, MI (N.R., D.L.N.); Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada (N.J.L.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, South Korea (B.-C.L., Y.K.); Department of Psychology, Hallym University, Chuncheon, South Korea (Y.K.); and Heart and Stroke Foundation Canadian Partnership for Stroke Recovery (K.H., S.E.B.).
Novena RangwalaFrom the L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.E.B.), Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., S.E.B.), Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.J.G., E.G., D.T.S., S.E.B.), Department of Medicine, Division of Neurology (R.T.M., B.L., K.H., R.D.H., A.A.M., F.Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., N.J.L , D.T.S., S.E.B.), Department of Medical Biophysics (S.J.G.), Rotman Research Institute, Baycrest (D.T.S., S.E.B.), and Department of Research Design and Biostatistics, Sunnybrook Health Sciences Centre (A.K.), University of Toronto, Toronto, ON, Canada; Departments of Radiology, Neurosurgery, and Bioengineering (X.J.Z.), and Department of Clinical Neuropsychology (N.R., D.L.N.), College of Medicine at Chicago, University of Illinois; Hauenstein Neuroscience Center, Saint Mary's Health Care, Grand Rapids, MI (N.R., D.L.N.); Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada (N.J.L.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, South Korea (B.-C.L., Y.K.); Department of Psychology, Hallym University, Chuncheon, South Korea (Y.K.); and Heart and Stroke Foundation Canadian Partnership for Stroke Recovery (K.H., S.E.B.).
Erin GibsonFrom the L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.E.B.), Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., S.E.B.), Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.J.G., E.G., D.T.S., S.E.B.), Department of Medicine, Division of Neurology (R.T.M., B.L., K.H., R.D.H., A.A.M., F.Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., N.J.L , D.T.S., S.E.B.), Department of Medical Biophysics (S.J.G.), Rotman Research Institute, Baycrest (D.T.S., S.E.B.), and Department of Research Design and Biostatistics, Sunnybrook Health Sciences Centre (A.K.), University of Toronto, Toronto, ON, Canada; Departments of Radiology, Neurosurgery, and Bioengineering (X.J.Z.), and Department of Clinical Neuropsychology (N.R., D.L.N.), College of Medicine at Chicago, University of Illinois; Hauenstein Neuroscience Center, Saint Mary's Health Care, Grand Rapids, MI (N.R., D.L.N.); Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada (N.J.L.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, South Korea (B.-C.L., Y.K.); Department of Psychology, Hallym University, Chuncheon, South Korea (Y.K.); and Heart and Stroke Foundation Canadian Partnership for Stroke Recovery (K.H., S.E.B.).
Nancy J LobaughFrom the L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.E.B.), Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., S.E.B.), Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.J.G., E.G., D.T.S., S.E.B.), Department of Medicine, Division of Neurology (R.T.M., B.L., K.H., R.D.H., A.A.M., F.Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., N.J.L , D.T.S., S.E.B.), Department of Medical Biophysics (S.J.G.), Rotman Research Institute, Baycrest (D.T.S., S.E.B.), and Department of Research Design and Biostatistics, Sunnybrook Health Sciences Centre (A.K.), University of Toronto, Toronto, ON, Canada; Departments of Radiology, Neurosurgery, and Bioengineering (X.J.Z.), and Department of Clinical Neuropsychology (N.R., D.L.N.), College of Medicine at Chicago, University of Illinois; Hauenstein Neuroscience Center, Saint Mary's Health Care, Grand Rapids, MI (N.R., D.L.N.); Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada (N.J.L.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, South Korea (B.-C.L., Y.K.); Department of Psychology, Hallym University, Chuncheon, South Korea (Y.K.); and Heart and Stroke Foundation Canadian Partnership for Stroke Recovery (K.H., S.E.B.).
Alex KissFrom the L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.E.B.), Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., S.E.B.), Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.J.G., E.G., D.T.S., S.E.B.), Department of Medicine, Division of Neurology (R.T.M., B.L., K.H., R.D.H., A.A.M., F.Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., N.J.L , D.T.S., S.E.B.), Department of Medical Biophysics (S.J.G.), Rotman Research Institute, Baycrest (D.T.S., S.E.B.), and Department of Research Design and Biostatistics, Sunnybrook Health Sciences Centre (A.K.), University of Toronto, Toronto, ON, Canada; Departments of Radiology, Neurosurgery, and Bioengineering (X.J.Z.), and Department of Clinical Neuropsychology (N.R., D.L.N.), College of Medicine at Chicago, University of Illinois; Hauenstein Neuroscience Center, Saint Mary's Health Care, Grand Rapids, MI (N.R., D.L.N.); Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada (N.J.L.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, South Korea (B.-C.L., Y.K.); Department of Psychology, Hallym University, Chuncheon, South Korea (Y.K.); and Heart and Stroke Foundation Canadian Partnership for Stroke Recovery (K.H., S.E.B.).
Donald T StussFrom the L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.E.B.), Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., S.E.B.), Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.J.G., E.G., D.T.S., S.E.B.), Department of Medicine, Division of Neurology (R.T.M., B.L., K.H., R.D.H., A.A.M., F.Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., N.J.L , D.T.S., S.E.B.), Department of Medical Biophysics (S.J.G.), Rotman Research Institute, Baycrest (D.T.S., S.E.B.), and Department of Research Design and Biostatistics, Sunnybrook Health Sciences Centre (A.K.), University of Toronto, Toronto, ON, Canada; Departments of Radiology, Neurosurgery, and Bioengineering (X.J.Z.), and Department of Clinical Neuropsychology (N.R., D.L.N.), College of Medicine at Chicago, University of Illinois; Hauenstein Neuroscience Center, Saint Mary's Health Care, Grand Rapids, MI (N.R., D.L.N.); Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada (N.J.L.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, South Korea (B.-C.L., Y.K.); Department of Psychology, Hallym University, Chuncheon, South Korea (Y.K.); and Heart and Stroke Foundation Canadian Partnership for Stroke Recovery (K.H., S.E.B.).
David L NyenhuisFrom the L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.E.B.), Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., S.E.B.), Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.J.G., E.G., D.T.S., S.E.B.), Department of Medicine, Division of Neurology (R.T.M., B.L., K.H., R.D.H., A.A.M., F.Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., N.J.L , D.T.S., S.E.B.), Department of Medical Biophysics (S.J.G.), Rotman Research Institute, Baycrest (D.T.S., S.E.B.), and Department of Research Design and Biostatistics, Sunnybrook Health Sciences Centre (A.K.), University of Toronto, Toronto, ON, Canada; Departments of Radiology, Neurosurgery, and Bioengineering (X.J.Z.), and Department of Clinical Neuropsychology (N.R., D.L.N.), College of Medicine at Chicago, University of Illinois; Hauenstein Neuroscience Center, Saint Mary's Health Care, Grand Rapids, MI (N.R., D.L.N.); Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada (N.J.L.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, South Korea (B.-C.L., Y.K.); Department of Psychology, Hallym University, Chuncheon, South Korea (Y.K.); and Heart and Stroke Foundation Canadian Partnership for Stroke Recovery (K.H., S.E.B.).
Byung-Chul LeeFrom the L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.E.B.), Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., S.E.B.), Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.J.G., E.G., D.T.S., S.E.B.), Department of Medicine, Division of Neurology (R.T.M., B.L., K.H., R.D.H., A.A.M., F.Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., N.J.L , D.T.S., S.E.B.), Department of Medical Biophysics (S.J.G.), Rotman Research Institute, Baycrest (D.T.S., S.E.B.), and Department of Research Design and Biostatistics, Sunnybrook Health Sciences Centre (A.K.), University of Toronto, Toronto, ON, Canada; Departments of Radiology, Neurosurgery, and Bioengineering (X.J.Z.), and Department of Clinical Neuropsychology (N.R., D.L.N.), College of Medicine at Chicago, University of Illinois; Hauenstein Neuroscience Center, Saint Mary's Health Care, Grand Rapids, MI (N.R., D.L.N.); Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada (N.J.L.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, South Korea (B.-C.L., Y.K.); Department of Psychology, Hallym University, Chuncheon, South Korea (Y.K.); and Heart and Stroke Foundation Canadian Partnership for Stroke Recovery (K.H., S.E.B.).
Yeonwook KangFrom the L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.E.B.), Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., S.E.B.), Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.J.G., E.G., D.T.S., S.E.B.), Department of Medicine, Division of Neurology (R.T.M., B.L., K.H., R.D.H., A.A.M., F.Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., N.J.L , D.T.S., S.E.B.), Department of Medical Biophysics (S.J.G.), Rotman Research Institute, Baycrest (D.T.S., S.E.B.), and Department of Research Design and Biostatistics, Sunnybrook Health Sciences Centre (A.K.), University of Toronto, Toronto, ON, Canada; Departments of Radiology, Neurosurgery, and Bioengineering (X.J.Z.), and Department of Clinical Neuropsychology (N.R., D.L.N.), College of Medicine at Chicago, University of Illinois; Hauenstein Neuroscience Center, Saint Mary's Health Care, Grand Rapids, MI (N.R., D.L.N.); Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada (N.J.L.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, South Korea (B.-C.L., Y.K.); Department of Psychology, Hallym University, Chuncheon, South Korea (Y.K.); and Heart and Stroke Foundation Canadian Partnership for Stroke Recovery (K.H., S.E.B.).
Sandra E BlackFrom the L.C. Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.E.B.), Heart and Stroke Foundation Centre for Stroke Recovery, Sunnybrook Health Sciences Centre (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., S.E.B.), Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute (R.T.M., B.L., K.H., R.D.H., A.A.M., F.-Q.G., J.R., C.J.M.S., A.G., J.Z., S.J.G., E.G., D.T.S., S.E.B.), Department of Medicine, Division of Neurology (R.T.M., B.L., K.H., R.D.H., A.A.M., F.Q.G., J.R., C.J.M.S., A.G., J.Z., E.G., N.J.L , D.T.S., S.E.B.), Department of Medical Biophysics (S.J.G.), Rotman Research Institute, Baycrest (D.T.S., S.E.B.), and Department of Research Design and Biostatistics, Sunnybrook Health Sciences Centre (A.K.), University of Toronto, Toronto, ON, Canada; Departments of Radiology, Neurosurgery, and Bioengineering (X.J.Z.), and Department of Clinical Neuropsychology (N.R., D.L.N.), College of Medicine at Chicago, University of Illinois; Hauenstein Neuroscience Center, Saint Mary's Health Care, Grand Rapids, MI (N.R., D.L.N.); Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada (N.J.L.); Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, South Korea (B.-C.L., Y.K.); Department of Psychology, Hallym University, Chuncheon, South Korea (Y.K.); and Heart and Stroke Foundation Canadian Partnership for Stroke Recovery (K.H., S.E.B.). sandra.black@sunnybrook.ca ykang@hallym.ac.kr.
Hallym University · KRCentre for Addiction and Mental Health · CAHallym University Sacred Heart Hospital · KRHealth Sciences Centre · CATrinity Health Grand Rapids · USUniversity of Illinois Chicago · USHeart and Stroke Foundation · CASunnybrook Health Science Centre · CA

Funding

Validation of the NINDS VCI Neuropsychology ProtocolsR01NS057514 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI NYENHUIS, DAVID L · 2007 to 2009
$1.5M
Canadian Institutes of Health Research MOP-13129NINDS NIH HHS NS 057514NINDS NIH HHS R01 NS057514
6 · The paper itself

Abstract

background and purposePoststroke cognitive impairment is typified by prominent deficits in processing speed and executive function. However, the underlying neuroanatomical substrates of executive deficits are not well understood, and further elucidation is needed. There may be utility in fractionating executive functions to delineate neural substrates.

methodsOne test amenable to fine delineation is the Trail Making Test (TMT), which emphasizes processing speed (TMT-A) and set shifting (TMT-B-A difference, proportion, quotient scores, and TMT-B set-shifting errors). The TMT was administered to 2 overt ischemic stroke cohorts from a multinational study: (1) a chronic stroke cohort (N=61) and (2) an acute-subacute stroke cohort (N=45). Volumetric quantification of ischemic stroke and white matter hyperintensities was done on magnetic resonance imaging, along with ratings of involvement of cholinergic projections, using the previously published cholinergic hyperintensities projections scale. Damage to the superior longitudinal fasciculus, which colocalizes with some cholinergic projections, was also documented.

resultsMultiple linear regression analyses were completed. Although larger infarcts (β=0.37, P<0.0001) were associated with slower processing speed, cholinergic hyperintensities projections scale severity (β=0.39, P<0.0001) was associated with all metrics of set shifting. Left superior longitudinal fasciculus damage, however, was only associated with the difference score (β=0.17, P=0.03). These findings were replicated in both cohorts. Patients with ≥2 TMT-B set-shifting errors also had greater cholinergic hyperintensities projections scale severity.

conclusionsIn this multinational stroke cohort study, damage to lateral cholinergic pathways and the superior longitudinal fasciculus emerged as significant neuroanatomical correlates for executive deficits in set shifting.

Indexed as

Trail Making TestAgedCognition DisordersCohort StudiesExecutive FunctionFemaleHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedNeuroimagingStrokecholinergic pathwaysexecutive functionsprocessing speedset shiftingsuperior longitudinal fasciculusTrail Making Testwhite matter hyperintensities

Identifiers

PMID26382176
PMCPMC4589519
OpenAlexW2124261664

What OpenQuestion holds

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Read underepoch 390

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None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.