Evidence map›Paper›PMID 26382033›Full record

ArticleMolecular brain2015

Fstl1 is involved in the regulation of radial glial scaffold development.

Rui Liu, Yang Yang, Junhui Shen, He Chen, Qianqian Zhang, Ru Ba, Yongjie Wei, Kai-Cheng Li, Xu Zhang, Chunjie Zhao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular brain, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Radial glia progenitor polarity in health and disease.Frontiers in cell and developmental biology · 2024
    Review
  5. PDK1 Regulates the Maintenance of Cell Body and the Development of Dendrites of Purkinje Cells by pS6 and PKCγ.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    Article
  6. Review
  7. Article
  8. Follistatin-like 1 in development and human diseases.Cellular and molecular life sciences : CMLS · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Rui LiuKey Laboratory of Developmental Genes and Human Diseases, MOE, Department of Anatomy and Neuroscience, Medical School, Southeast University, Nanjing, 210009, China. ruiliu_1986@sina.com.
Yang YangKey Laboratory of Developmental Genes and Human Diseases, MOE, Department of Anatomy and Neuroscience, Medical School, Southeast University, Nanjing, 210009, China. ate5455@163.com.
Junhui ShenKey Laboratory of Developmental Genes and Human Diseases, MOE, Department of Anatomy and Neuroscience, Medical School, Southeast University, Nanjing, 210009, China. 961240280@qq.com.
He ChenKey Laboratory of Developmental Genes and Human Diseases, MOE, Department of Anatomy and Neuroscience, Medical School, Southeast University, Nanjing, 210009, China. m15850656172@163.com.
Qianqian ZhangKey Laboratory of Developmental Genes and Human Diseases, MOE, Department of Anatomy and Neuroscience, Medical School, Southeast University, Nanjing, 210009, China. 1558579563@qq.com.
Ru BaKey Laboratory of Developmental Genes and Human Diseases, MOE, Department of Anatomy and Neuroscience, Medical School, Southeast University, Nanjing, 210009, China. 1093802727@qq.com.
Yongjie WeiKey Laboratory of Developmental Genes and Human Diseases, MOE, Department of Anatomy and Neuroscience, Medical School, Southeast University, Nanjing, 210009, China. i1206j@qq.com.
Kai-Cheng LiInstitute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. kaichengl@yahoo.com.
Xu ZhangInstitute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. xu.zhang@ion.ac.cn.
Chunjie ZhaoKey Laboratory of Developmental Genes and Human Diseases, MOE, Department of Anatomy and Neuroscience, Medical School, Southeast University, Nanjing, 210009, China. zhaocj@seu.edu.cn.
Southeast University · CNChinese Academy of Sciences · CNChinese Institute for Brain Research · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRadial glial cells (RGCs), the instructive scaffolds for neuronal migration, are well characterized by their unique morphology and polarization; these cells extend elongated basal processes to the pial basement membrane (BM) and parallel to one another. However, little is known about the mechanisms that underlie the developmental regulation and maintenance of this unique morphology.

resultsHere, by crossing Fstl1 (fl/fl) mice with an EIIa-Cre line, we identified a new role for the secreted glycoprotein Follistatin like-1 (FSTL1). The ablation of Fstl1 in both of its cortical expression domains, the ventricular zone (VZ) and the pia mater, resulted in RGC morphologic disruption; basal processes were not parallel to each other, and endfeet exhibited greater density and branching. However, Fstl1 deletion in only the VZ in the Emx1 (IREScre); Fstl1 (fl/fl) line did not affect RGC morphology, indicating that FSTL1 derived from the pia mater might be more important for RGC morphology. In addition, upper-layer projection neurons, not deeper-layer projection neurons, failed to reach their appropriate positions. We also found that BMP, AKT/PKB, Cdc42, GSK3β, integrin and reelin signals, which have previously been reported to regulate RGC development, were unchanged, indicating that Fstl1 may function through a unique mechanism.

conclusionsIn the present study, we identified a new role for FSTL1 in the development of radial glial scaffolds and the neuronal migration of upper-layer projection neurons. Our findings will improve understanding of the regulation of RGC development and neuronal migration.

Indexed as

AnimalsBasement MembraneCell PolarityCell ShapeCerebral CortexCerebral VentriclesFollistatin-Related ProteinsGene DeletionMiceNeurogliaPia MaterReelin ProteinFollistatin-Related ProteinsFstl1 protein, mouseReelin ProteinRELN protein, humanReln protein, mouse

Identifiers

PMID26382033
PMCPMC4573935
OpenAlexW1923499094

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.