Evidence map›Paper›PMID 26381872›Full record

ReviewJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2015

Vascular and plaque imaging with ultrasmall superparamagnetic particles of iron oxide.

Shirjel R Alam, Colin Stirrat, Jennifer Richards, Saeed Mirsadraee, Scott I K Semple, George Tse, Peter Henriksen, David E Newby

Abstract readReview
In one paragraph

Review in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Ferumoxytol-enhanced cardiovascular magnetic resonance imaging: applications and technical advances.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Diagnostics of atherosclerosis: Overview of the existing methods.Frontiers in cardiovascular medicine · 2023
    Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Different Approaches to Develop Nanosensors for Diagnosis of Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Macrophage Imaging of Intracranial Aneurysms.Neurologia medico-chirurgica · 2019
    Review
  18. Review
  19. Manganese-Enhanced TContrast media & molecular imaging · 2018
    Article
  20. Review of Journal of Cardiovascular Magnetic Resonance (JCMR) 2015-2016 and transition of the JCMR office to Boston.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shirjel R AlamCentre for Cardiovascular Science, The University of Edinburgh, The Chancellor's Building, Little France Crescent, Edinburgh, EH16 5SA, UK. s.r.alam@sms.ed.ac.uk.
Colin StirratCentre for Cardiovascular Science, The University of Edinburgh, The Chancellor's Building, Little France Crescent, Edinburgh, EH16 5SA, UK. cstirrat@exseed.ed.ac.uk.
Jennifer RichardsCentre for Cardiovascular Science, The University of Edinburgh, The Chancellor's Building, Little France Crescent, Edinburgh, EH16 5SA, UK. jenny.Robson@ed.ac.uk.
Saeed MirsadraeeClinical Research Imaging Centre, University of Edinburgh, Edinburgh, EH16 5SA, UK. Saeed.Mirsadraee@ed.ac.uk.
Scott I K SempleClinical Research Imaging Centre, University of Edinburgh, Edinburgh, EH16 5SA, UK. scott.semple@ed.ac.u.
George TseMRC Centre for Inflammation Research, The University of Edinburgh, Edinburgh, EH16 5SA, UK. gtse@staffmail.ed.ac.uk.
Peter HenriksenCentre for Cardiovascular Science, The University of Edinburgh, The Chancellor's Building, Little France Crescent, Edinburgh, EH16 5SA, UK. peter.Henriksen@nhslothian.scot.nhs.uk.
David E NewbyCentre for Cardiovascular Science, The University of Edinburgh, The Chancellor's Building, Little France Crescent, Edinburgh, EH16 5SA, UK. D.E.Newby@ed.ac.uk.

Funding

British Heart Foundation CH/09/002British Heart Foundation FS/12/83British Heart Foundation FS/12/83/29781British Heart Foundation RE/08/001Chief Scientist Office ETM/266Medical Research Council G0701127Medical Research Council G1001339Wellcome Trust 103782
6 · The paper itself

Abstract

Cardiovascular Magnetic Resonance (CMR) has become a primary tool for non-invasive assessment of cardiovascular anatomy, pathology and function. Existing contrast agents have been utilised for the identification of infarction, fibrosis, perfusion deficits and for angiography. Novel ultrasmall superparamagnetic particles of iron oxide (USPIO) contrast agents that are taken up by inflammatory cells can detect cellular inflammation non-invasively using CMR, potentially aiding the diagnosis of inflammatory medical conditions, guiding their treatment and giving insight into their pathophysiology. In this review we describe the utilization of USPIO as a novel contrast agent in vascular disease.

Indexed as

Plaque, AtheroscleroticAnimalsArteriesAtherosclerosisContrast MediaDextransHumansInflammationMacrophagesMagnetic Resonance ImagingMagnetite NanoparticlesParticle SizePredictive Value of TestsPrognosisContrast MediaDextransferumoxtran-10Magnetite Nanoparticles

Identifiers

PMID26381872
PMCPMC4574723

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.