ArticleFuture oncology (London, England)2015
Urotensin II receptor on preoperative biopsy is associated with upstaging and upgrading in prostate cancer.
Article in Future oncology (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Pooled it
- Role of Rs228648 and Rs2890565 single nucleotide polymorphisms in Urotensin-2 gene in prostate cancer.Molecular biology reports · 2025Article
- Prognostic Significance and Functional Mechanism of UTS2 in Glioblastoma Multiforme.Current cancer drug targets · 2025Article
- The Effect of Local Renin Angiotensin System in the Common Types of Cancer.Frontiers in endocrinology · 2021Review
- Gene expression analysis of human prostate cell lines with and without tumor metastasis suppressor CD82.BMC cancer · 2020Article
- Analysis of key genes reveal lysine demethylase 5B promotes prostate cancer progression.Oncology letters · 2020Article
- Article
- XPC exon15 Lys939Gln variant increase susceptibility to prostate adenocarcinoma: Evidence based on 4306 patients and 4779 controls.Medicine · 2020Article
- Is elevated urotensin II level a predictor for increased cardiovascular risk in subjects with acromegaly?Journal of endocrinological investigation · 2019Article
- Urotensin II receptor as a potential biomarker for the prognosis of hepatocellular carcinoma patients.Oncology letters · 2017Article
- Micrornas in prostate cancer: an overview.Oncotarget · 2017Review
- The emerging role of obesity, diet and lipid metabolism in prostate cancer.Future oncology (London, England) · 2017Review
- The presence of primary circulating prostate cells is associated with upgrading and upstaging in patients eligible for active surveillance.Ecancermedicalscience · 2017Article
- Observational
Corrections and comments
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Authors and funding
21 authors at 12 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimA higher Gleason score was associated with a lower tumor urotensin II receptor (UTII-R) expression in prostate cancer patients.
methodsA retrospective review of formalin-fixed paraffin-embedded tumor tissue derived from those who had prostatectomy and matching biopsy specimens was conducted at six Institutions. UTII-R expression was evaluated on biopsy by immunohistochemistry.
resultsA total of 58 subjects undergoing radical prostatectomy were included. At multivariate analysis, low UTII-R expression was a significant predictor of Gleason upgrading, with an odds ratio of 10.3 (95% CI: 1.55-68.4), and of pathology upstaging, with an odds ratio of 11.1 (95% CI: 1.23-100.48).
conclusionsUTII-R expression on biopsy was associated with Gleason upgrading and pathology upstaging in prostate cancer patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.