Evidence map›Paper›PMID 26381810›Full record

ArticlePhysical therapy2016

BDNF Val66Met Polymorphism Is Related to Motor System Function After Stroke.

Dae Yul Kim, Erin B Quinlan, Robert Gramer, Steven C Cramer

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physical therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. BDNF: New Views of an Old Player in Traumatic Brain Injury.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024
    Review
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  20. Genetic Variation and Neuroplasticity: Role in Rehabilitation After Stroke.Journal of neurologic physical therapy : JNPT · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Dae Yul KimD.Y. Kim, MD, Department of Rehabilitation, University of Ulsan, Ulsan, Korea.
Erin B QuinlanE.B. Quinlan, PhD, Department of Neurology, University of California at Irvine, Irvine, California.
Robert GramerR. Gramer, BA, Department of Neurology, University of California at Irvine.
Steven C CramerS.C. Cramer, MD, MMSc, Department of Neurology, University of California at Irvine, Hewitt Hall, Room 1331, Mail Code 1385, Irvine, CA 92697 (USA). scramer@uci.edu.
University of California, Irvine · USUniversity of Ulsan · KR

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Institute for Clinical and Translational ScienceUL1TR000153 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M · 2012 to 2015
$12.1M
Motor Function after StrokeR01NS059909 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CRAMER, STEVEN C. · 2009 to 2013
$2.0M
Brain plasticity and rehabilitation after strokeK24HD074722 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI CRAMER, STEVEN C. · 2013 to 2017
$588k
NCATS NIH HHS UL1 TR000153NCATS NIH HHS UL1 TR001414NICHD NIH HHS 1K24 HD074722 01NICHD NIH HHS K24 HD074722NINDS NIH HHS R01 NS059909
6 · The paper itself

Abstract

backgroundThe val(66)met polymorphism in brain-derived neurotrophic factor (BDNF) has been associated with poorer outcomes after stroke. The mechanism for this finding remains uncertain but might be related to the reduced motor system activation associated with this polymorphism in healthy people.

objectiveThe current study examined whether the presence of the BDNF val(66)met polymorphism is associated with reduced motor system activation after stroke. DESIGN AND

methodsForty-two patients with stroke who were enrolled in 1 of 2 studies of robot-assisted arm motor therapy participated in the study. All participants were tested for the BDNF val(66)met polymorphism followed by functional magnetic resonance imaging during affected hand movement.

resultsParticipants averaged 12 months poststroke and had wide-ranging motor deficits (Fugl-Meyer scale scores=14-60). Brain activation in participants without the BDNF val(66)met polymorphism (n=26) spanned bilateral motor networks with a larger volume (total=334 cc) than that found in participants with this polymorphism (n=16) (97 cc). Regional analyses were consistent. Participants without this polymorphism showed larger ipsilesional primary sensorimotor cortex activation volume and magnitude compared with those in whom the polymorphism was present. LIMITATIONS: The extent to which these findings generalize to other populations of people with stroke, such as those with stroke <7 days prior, remains uncertain.

conclusionsFunctional magnetic resonance imaging during affected hand movement showed decreased brain activation among participants with the BDNF val(66)met polymorphism compared with those lacking this polymorphism, especially in the ipsilesional primary sensorimotor cortex contralateral to movement. These results echo findings in healthy people and suggest that genetic factors affecting the normal brain continue to be operative after stroke. The findings suggest a potential imaging-based endophenotype for the BDNF val(66)met polymorphism's effect on the motor system that may be useful in a clinical trial setting.

Indexed as

Polymorphism, Single NucleotideStroke RehabilitationBrain-Derived Neurotrophic FactorDisability EvaluationFemaleGenotypeHandHumansMagnetic Resonance ImagingMaleMiddle AgedRecovery of FunctionSensorimotor CortexStrokeBDNF protein, humanBrain-Derived Neurotrophic Factor

Identifiers

PMID26381810
PMCPMC4817211
OpenAlexW2275522537

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.