ArticleAJNR. American journal of neuroradiology2016
The Arcuate Fasciculus and Language Development in a Cohort of Pediatric Patients with Malformations of Cortical Development.
Article in AJNR. American journal of neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 17 citations in OpenAlex.
- Language laterality and cognitive skills: does anatomy matter?Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Selective Alteration of the Left Arcuate Fasciculus in Two Patients Affected by Creatine Transporter Deficiency.Brain sciences · 2024Article
- White matter association tracts underlying language and theory of mind: An investigation of 809 brains from the Human Connectome Project.NeuroImage · 2022Article
- Understanding Language Reorganization With Neuroimaging: How Language Adapts to Different Focal Lesions and Insights Into Clinical Applications.Frontiers in human neuroscience · 2022Review
- Symptom-Related Differential Neuroimaging Biomarkers in Children with Corpus Callosum Abnormalities.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Functional Contributions of the Arcuate Fasciculus to Language Processing.Frontiers in human neuroscience · 2021Article
- Characterizing White Matter Tract Organization in Polymicrogyria and Lissencephaly: A Multifiber Diffusion MRI Modeling and Tractography Study.AJNR. American journal of neuroradiology · 2020Article
- Utility of MRI, PET, and ictal SPECT in presurgical evaluation of non-lesional pediatric epilepsy.Seizure · 2020Review
- Developmental Dynamic Dysphasia: Are Bilateral Brain Abnormalities a Signature of Inefficient Neural Plasticity?Frontiers in human neuroscience · 2020Article
- Altered White Matter Organization in the TUBB3 E410K Syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Language ability in preterm children is associated with arcuate fasciculi microstructure at term.Human brain mapping · 2017Article
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3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposePatients with epilepsy and malformations of cortical development have a high prevalence of language deficits. The purpose of this study was to investigate whether the status of the arcuate fasciculus at diffusion tractography could provide a clinically meaningful marker of language function in patients with cortical malformations. MATERIALS AND
methodsThirty-seven patients 3-18 years of age who had DTI performed at 3T and language evaluation by a pediatric neurologist were retrospectively identified. Twenty-two age-matched children without any neurologic, language, or MR imaging abnormalities who had identical DTI performed for an indication of headache were selected as a control cohort. The arcuate fasciculi were constructed and segmented by deterministic tractography for all subjects.
resultsTwenty-one patients had intact language; 11 had mild-to-moderate and 5, profound language impairment. All patients with normal language and all control subjects had an identifiable left arcuate. The left arcuate was absent in 11 patients; all 11 were language-impaired. Failure to identify the left arcuate was strongly associated with some degree of language impairment (P < .001). Sensitivity, specificity, and positive predictive value for language dysfunction were 65%, 100%, and 100%, respectively. The absence of the arcuate bilaterally was associated with complete failure to develop oral language (P < .015).
conclusionsFailure to identify the left arcuate fasciculus at diffusion tractography was a highly specific marker of language dysfunction in a cohort of pediatric patients with malformations of cortical development. Failure to identify the arcuate fasciculus on either side was associated with failure to develop oral language.
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