Evidence map›Paper›PMID 26381107›Full record

ArticleOrganic & biomolecular chemistry2015

A latent reactive handle for functionalising heparin-like and LMWH deca- and dodecasaccharides.

Gavin J Miller, Karl R Broberg, Claire Rudd, Madeleine R Helliwell, Gordon C Jayson, John M Gardiner

Abstract read
In one paragraph

Article in Organic & biomolecular chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Single-Molecule Fluorescence Detection of a Synthetic Heparan Sulfate Disaccharide.Chemphyschem : a European journal of chemical physics and physical chemistry · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gavin J MillerManchester Institute of Biotechnology and School of Chemistry, 131 Princess Street, University of Manchester M1 7DN, UK. gardiner@manchester.ac.uk.
Karl R Broberg
Claire Rudd
Madeleine R Helliwell
Gordon C Jayson
John M Gardiner

Funding

Cancer Research UK C2075/A9106Medical Research Council G0601746Medical Research Council G0902173Medical Research Council G902173
6 · The paper itself

Abstract

d-Glucosamine derivatives bearing latent O4 functionality provide modified H/HS-type disaccharide donors for a final stage capping approach enabling introduction of conjugation-suitable, non-reducing terminal functionality to biologically important glycosaminoglycan oligosaccharides. Application to the synthesis of the first O4-terminus modified synthetic LMWH decasaccharide and an HS-like dodecasaccharide is reported.

Indexed as

AlkylationAnticoagulantsCrystallography, X-RayDisaccharidesGlucosamineGlycosaminoglycansHeparinHeparin, Low-Molecular-WeightModels, MolecularOligosaccharidesAnticoagulantsDisaccharidesGlucosamineGlycosaminoglycansHeparinHeparin, Low-Molecular-WeightOligosaccharides

Identifiers

PMID26381107
PMCPMC4672752

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.