ArticlePhysiological reports2015
Effects of leptin on sympathetic nerve activity in conscious mice.
Article in Physiological reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- Comparison of Serum Interleukin 6, Leptin, and Adiponectin Levels after Cesarean Section Under General Versus Spinal Anesthesia.Anesthesiology and pain medicine · 2025Article
- Activation of hypothalamic AgRP and POMC neurons evokes disparate sympathetic and cardiovascular responses.American journal of physiology. Heart and circulatory physiology · 2020Article
- Cardiovascular Regulation by the Neuronal BBSome.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Afferent innervation of the ischemic kidney contributes to renal dysfunction in renovascular hypertensive rats.Pflugers Archiv : European journal of physiology · 2020Article
- Renal denervation reduces sympathetic overactivation, brain oxidative stress, and renal injury in rats with renovascular hypertension independent of its effects on reducing blood pressure.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- External light activates hair follicle stem cells through eyes via an ipRGC-SCN-sympathetic neural pathway.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Novel Approach for Simultaneous Recording of Renal Sympathetic Nerve Activity and Blood Pressure with Intravenous Infusion in Conscious, Unrestrained Mice.Journal of visualized experiments : JoVE · 2018Article
- Differential contribution of POMC and AgRP neurons to the regulation of regional autonomic nerve activity by leptin.Molecular metabolism · 2018Article
- Reduced renal sympathetic nerve activity contributes to elevated glycosuria and improved glucose tolerance in hypothalamus-specific Pomc knockout mice.Molecular metabolism · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The adipocyte-derived hormone, leptin, has emerged as an important regulator of regional sympathetic nerve activity (SNA) with pathophysiological implications in obesity. Genetically engineered mice are useful to understand the molecular pathways underlying the SNA responses evoked by leptin. However, so far the effect of leptin on direct SNA in mice has been studied under general anesthesia. Here, we examined the sympathetic responses evoked by leptin in conscious mice. Mice were instrumented, under ketamine/xylazine anesthesia, with renal or lumbar SNA recordings using a thin (40 gauge) bipolar platinum-iridium wire. The electrodes were exteriorized at the nape of the neck and mice were allowed (5 h) to recover from anesthesia. Interestingly, the reflex increases in renal and lumbar SNA caused by sodium nitroprusside (SNP)-induced hypotension was higher in the conscious phase versus the anesthetized state, whereas the increase in both renal and lumbar SNA evoked by leptin did not differ between anesthetized or conscious mice. Next, we assessed whether isoflurane anesthesia would yield a better outcome. Again, the SNP-induced increase in renal SNA and baroreceptor-renal SNA reflex were significantly elevated in the conscious states relative to isoflurane-anesthetized phase, but the renal SNA response induced by leptin in the conscious states were qualitatively comparable to those evoked above. Thus, despite improvement in sympathetic reflexes in conscious mice the sympathetic responses evoked by leptin mimic those induced during anesthesia.
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