Evidence map›Paper›PMID 26380981›Full record

ArticleMetabolic brain disease2015

Exposure to ethanol during neurodevelopment modifies crucial offspring rat brain enzyme activities in a region-specific manner.

Vasileios Stolakis, Charis Liapi, Apostolos Zarros, Konstantina Kalopita, Vassilios Memtsas, John Botis, Anastasia Tsagianni, Despoina Kimpizi, Alexios Varatsos, Stylianos Tsakiris

Abstract read
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In one paragraph

Article in Metabolic brain disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Vasileios StolakisLaboratory of Pharmacology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Charis LiapiLaboratory of Pharmacology, Medical School, National and Kapodistrian University of Athens, Athens, Greece. cliapi@med.uoa.gr.
Apostolos ZarrosLaboratory of Physiology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias street, GR-11527, Athens, Greece.
Konstantina KalopitaLaboratory of Physiology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias street, GR-11527, Athens, Greece.
Vassilios MemtsasLaboratory of Physiology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias street, GR-11527, Athens, Greece.
John BotisLaboratory of Physiology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias street, GR-11527, Athens, Greece.
Anastasia TsagianniLaboratory of Physiology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias street, GR-11527, Athens, Greece.
Despoina KimpiziLaboratory of Physiology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias street, GR-11527, Athens, Greece.
Alexios VaratsosDepartment of Pathology, Panarcadic General Hospital, Tripolis, Greece.
Stylianos TsakirisLaboratory of Physiology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias street, GR-11527, Athens, Greece. stsakir@med.uoa.gr.
National and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The experimental simulation of conditions falling within "the fetal alcohol spectrum disorder" (FASD) requires the maternal exposure to ethanol (EtOH) during crucial neurodevelopmental periods; EtOH has been linked to a number of neurotoxic effects on the fetus, which are dependent upon the extent and the magnitude of the maternal exposure to EtOH and for which very little is known with regard to the exact mechanism(s) involved. The current study has examined the effects of moderate maternal exposure to EtOH (10 % v/v in the drinking water) throughout gestation, or gestation and lactation, on crucial 21-day-old offspring Wistar rat brain parameters, such as the activities of acetylcholinesterase (AChE) and two adenosine triphosphatases (Na(+),K(+)-ATPase and Mg(2+)-ATPase), in major offspring CNS regions (frontal cortex, hippocampus, hypothalamus, cerebellum and pons). The implemented experimental setting has provided a comparative view of the neurotoxic effects of maternal exposure to EtOH between gestation alone and a wider exposure timeframe that better covers the human third trimester-matching CNS neurodevelopment period (gestation and lactation), and has revealed a CNS region-specific susceptibility of the examined crucial neurochemical parameters to the EtOH exposure schemes attempted. Amongst these parameters, of particular importance is the recorded extensive stimulation of Na(+),K(+)-ATPase in the frontal cortex of the EtOH-exposed offspring that seems to be a result of the deleterious effect of EtOH during gestation. Although this stimulation could be inversely related to the observed inhibition of AChE in the same CNS region, its dependency upon the EtOH-induced modulation of other systems of neurotransmission cannot be excluded and must be further clarified in future experimental attempts aiming to simulate and to shed more light on the milder forms of the FASD-related pathophysiology.

Indexed as

AcetylcholinesteraseAnimalsAnimals, NewbornBrainCa(2+) Mg(2+)-ATPaseCentral Nervous System DepressantsEthanolFemaleFetal Alcohol Spectrum DisordersLactationPregnancyPrenatal Exposure Delayed EffectsRatsRats, WistarSodium-Potassium-Exchanging ATPaseAcetylcholinesteraseCa(2+) Mg(2+)-ATPaseCentral Nervous System DepressantsEthanolSodium-Potassium-Exchanging ATPaseAcetylcholinesteraseAdenosinetriphosphataseCerebellumEthanolFetal alcohol spectrum disordersFetal alcohol syndromeFrontal cortexHippocampusHypothalamusMg2+-ATPaseNa+,K+-ATPasePonsRat brain

Identifiers

PMID26380981
OpenAlexW1868995945

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.