Evidence map›Paper›PMID 26380951›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2016

Striatal and Cortical β-Amyloidopathy and Cognition in Parkinson's Disease.

Neha Shah, Kirk A Frey, Martijn L T M Müller, Myria Petrou, Vikas Kotagal, Robert A Koeppe, Peter J H Scott, Roger L Albin, Nicolaas I Bohnen

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Movement disorders : official journal of the Movement Disorder Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04250376 (The Use of Transcranial Focused Ultrasound for the Treatment of Neurodegenerative Dementias), which is not on this map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04250376 naunknown statusnot on this mapstarted 2017, after this paper: background citation

The Use of Transcranial Focused Ultrasound for the Treatment of Neurodegenerative Dementias

TypeinterventionalSponsorNeurological Associates of West Los AngelesRan2017 to 2025Enrolled100ConditionsMild Cognitive Impairment, Mild Dementia, Parkinson Disease, Alzheimer DiseaseArmsFocused Transcranial Ultrasound
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Morphological basis of Parkinson disease-associated cognitive impairment: an update.Journal of neural transmission (Vienna, Austria : 1996) · 2022
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Nutritional Ketosis in Parkinson's Disease - a Review of Remaining Questions and Insights.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Review
  17. Lewy Body Dementias: A Coin with Two Sides?Behavioral sciences (Basel, Switzerland) · 2021
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Neha ShahDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
Kirk A FreyDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
Martijn L T M MüllerDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
Myria PetrouDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
Vikas KotagalDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Robert A KoeppeDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
Peter J H ScottDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
Roger L AlbinDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Nicolaas I BohnenDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA.

Funding

Tomography and Data AnalysisP01NS015655 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GILMAN, SID · 1985 to 2012
$13.0M
Public Outreach and Education CoreP50NS091856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALBIN, ROGER L · 2014 to 2019
$10.1M
Hyposmia, Cholinergic Denervation and Incipient Cognitive Decline in PDR01NS070856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOHNEN, NICOLAAS IDA · 2010 to 2014
$1.9M
IMAGING BIOMARKERS OF PROGRESSION OF MOBILITY IMPAIRMENT IN PDI01RX000317 · VA · VETERANS HEALTH ADMINISTRATION · PI BOHNEN, NICOLAAS IDA · 2012 to 2014
–
NINDS NIH HHS P01 NS015655NINDS NIH HHS P50 NS091856NINDS NIH HHS R01 NS070856RRD VA I01 RX000317
6 · The paper itself

Abstract

introductionAlthough most previous cognitive studies of β-amyloidopathy in PD focused on cortical plaque deposition, recent postmortem studies point to an important role of striatal β-amyloid plaque deposition. The aim of this study was to investigate the relative contributions of striatal and cortical β-amyloidopathy to cognitive impairment in PD.

methodsPatients with PD (n = 62; age, 68.9 ± 6.4 years; H & Y stage: 2.7 ± 0.5; MoCA score: 25.2 ± 3.0) underwent [(11) C]Pittsburgh compound B β-amyloid, [(11) C]dihydrotetrabenazine monoaminergic, and [(11) C]methyl-4-piperidinyl propionate acetylcholinesterase brain PET imaging and neuropsychological assessment. [(11) C]Pittsburgh compound B β-amyloid data from young to middle-aged healthy subjects were used to define elevated [(11) C]Pittsburgh compound B binding in patients.

resultsElevated cortical and striatal β-amyloid deposition were present in 37% and 16%, respectively, of this predominantly nondemented cohort of patients with PD. Increased striatal β-amyloid deposition occurred in half of all subjects with increased cortical β-amyloid deposition. In contrast, increased striatal β-amyloid deposition did not occur in the absence of increased cortical β-amyloid deposition. Analysis of covariance using global composite cognitive z scores as the outcome parameter showed significant regressor effects for combined striatal and cortical β-amyloidopathy (F = 4.18; P = 0.02) after adjusting for covariate effects of cortical cholinergic activity (F = 5.67; P = 0.02), caudate nucleus monoaminergic binding, duration of disease, and age (total model: F = 3.55; P = 0.0048). Post-hoc analysis showed significantly lower cognitive z score for combined striatal and cortical β-amyloidopathy, compared to cortical-only β-amyloidopathy and non-β-amyloidopathy subgroups.

conclusionsThe combined presence of striatal and cortical β-amyloidopathy is associated with greater cognitive impairment than cortical β-amyloidopathy alone in PD.

Indexed as

AgedAged, 80 and overAmyloid beta-PeptidesAnalysis of VarianceAniline CompoundsCarbon IsotopesCerebral CortexCognition DisordersCorpus StriatumCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedParkinson Disease2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazoleAmyloid beta-PeptidesAniline CompoundsCarbon IsotopesdihydrotetrabenazineTetrabenazineThiazolesacetylcholinesterasecognitive impairmentcortexdopamineParkinson's diseasePETstriatumβ-amyloid

Identifiers

PMID26380951
PMCPMC4724301

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.