Evidence map›Paper›PMID 26380772›Full record

ArticleJournal of thoracic disease2015

Functional residual capacity in beagle dogs with and without acute respiratory distress syndrome.

Qi Liu, Yong-Hua Gao, Dong-Ming Hua, Wen Li, Zhe Cheng, Hui Zheng, Rong-Chang Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Qi Liu1 Department of Respiratory and Critical Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China ; 2 Respiratory Mechanics Lab, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510182, China ; 3 Department of Radiology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510182, China ; 4 Department of Radiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Yong-Hua Gao1 Department of Respiratory and Critical Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China ; 2 Respiratory Mechanics Lab, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510182, China ; 3 Department of Radiology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510182, China ; 4 Department of Radiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Dong-Ming Hua1 Department of Respiratory and Critical Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China ; 2 Respiratory Mechanics Lab, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510182, China ; 3 Department of Radiology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510182, China ; 4 Department of Radiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Wen Li1 Department of Respiratory and Critical Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China ; 2 Respiratory Mechanics Lab, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510182, China ; 3 Department of Radiology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510182, China ; 4 Department of Radiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Zhe Cheng1 Department of Respiratory and Critical Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China ; 2 Respiratory Mechanics Lab, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510182, China ; 3 Department of Radiology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510182, China ; 4 Department of Radiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Hui Zheng1 Department of Respiratory and Critical Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China ; 2 Respiratory Mechanics Lab, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510182, China ; 3 Department of Radiology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510182, China ; 4 Department of Radiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Rong-Chang Chen1 Department of Respiratory and Critical Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China ; 2 Respiratory Mechanics Lab, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510182, China ; 3 Department of Radiology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510182, China ; 4 Department of Radiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
First Affiliated Hospital of Guangzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTraditionally, the choice of tidal volume for mechanical ventilation was based on body weight (BW) and usually, predicted BW was used to correct actual BW inter-individual variations in obesity and muscle weight. The method of selecting tidal volume depended on the fact that normal lung volumes, especially functional residual capacity (FRC), were mainly determined by height (indirectly by predicted BW), sex and age in healthy persons. However, FRCs in patients with acute respiratory distress syndrome (ARDS) might not abide by the same rule and be significantly different from each other in patients with the same height and sex. We hypothesized that FRC was determined by body length (surrogate for predicted BW) and age in healthy male beagle dogs but not in lung injured ones.

methodsA total of 24 dogs were recruited and ARDS model was induced by intravenous injection of oleic acid. FRC was measured by chest computer tomography. Blood gas analysis, extra vascular lung water and respiratory system mechanics were tested at baseline and post-lung injury. Age, body length and actual BW were also recorded before experiments.

resultsAfter lung injury, FRC decreased sharply from baseline (414±84) to (214±70) mL. For healthy lungs, FRC could be estimated by the following formula: FRC =21.86 × age (months) + 20.55 × body length (cm) - 1,337.98 (P<0.05), while for injured lungs, the formula of multiple linear regression was invalid (P=0.305).

conclusionsFRC was linearly related to body length in healthy dogs but not in lung injured ones. The traditional view of setting tidal volume based on predicted BW should be challenged cautiously.

Indexed as

Functional residual capacity (FRC)lung protective ventilationpredicted body weight (BW)tidal volume

Identifiers

PMID26380772
PMCPMC4561278
OpenAlexW1959601505

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.