Evidence map›Paper›PMID 26380766›Full record

ArticleJournal of thoracic disease2015

Identification of immunohistochemical markers for distinguishing lung adenocarcinoma from squamous cell carcinoma.

Cheng Zhan, Li Yan, Lin Wang, Yang Sun, Xingxing Wang, Zongwu Lin, Yongxing Zhang, Yu Shi, Wei Jiang, Qun Wang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 74 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Cheng Zhan1 Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China ; 2 Department of Radiation Oncology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China ; 3 Department of Stomatology, Zhongshan Hospital, Fudan University, Shanghai 200032, China ; 4 Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Li Yan1 Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China ; 2 Department of Radiation Oncology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China ; 3 Department of Stomatology, Zhongshan Hospital, Fudan University, Shanghai 200032, China ; 4 Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Lin Wang1 Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China ; 2 Department of Radiation Oncology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China ; 3 Department of Stomatology, Zhongshan Hospital, Fudan University, Shanghai 200032, China ; 4 Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Yang Sun1 Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China ; 2 Department of Radiation Oncology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China ; 3 Department of Stomatology, Zhongshan Hospital, Fudan University, Shanghai 200032, China ; 4 Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Xingxing Wang1 Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China ; 2 Department of Radiation Oncology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China ; 3 Department of Stomatology, Zhongshan Hospital, Fudan University, Shanghai 200032, China ; 4 Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Zongwu Lin1 Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China ; 2 Department of Radiation Oncology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China ; 3 Department of Stomatology, Zhongshan Hospital, Fudan University, Shanghai 200032, China ; 4 Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Yongxing Zhang1 Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China ; 2 Department of Radiation Oncology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China ; 3 Department of Stomatology, Zhongshan Hospital, Fudan University, Shanghai 200032, China ; 4 Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Yu Shi1 Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China ; 2 Department of Radiation Oncology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China ; 3 Department of Stomatology, Zhongshan Hospital, Fudan University, Shanghai 200032, China ; 4 Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Wei Jiang1 Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China ; 2 Department of Radiation Oncology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China ; 3 Department of Stomatology, Zhongshan Hospital, Fudan University, Shanghai 200032, China ; 4 Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Qun Wang1 Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China ; 2 Department of Radiation Oncology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China ; 3 Department of Stomatology, Zhongshan Hospital, Fudan University, Shanghai 200032, China ; 4 Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImmunohistochemical staining has been widely used in distinguishing lung adenocarcinoma (LUAD) from lung squamous cell carcinoma (LUSC), which is of vital importance for the diagnosis and treatment of lung cancer. Due to the lack of a comprehensive analysis of different lung cancer subtypes, there may still be undiscovered markers with higher diagnostic accuracy.

methodsHerein first, we systematically analyzed high-throughput data obtained from The Cancer Genome Atlas (TCGA) database. Combining differently expressed gene screening and receiver operating characteristic (ROC) curve analysis, we attempted to identify the genes which might be suitable as immunohistochemical markers in distinguishing LUAD from LUSC. Then we detected the expression of six of these genes (MLPH, TMC5, SFTA3, DSG3, DSC3 and CALML3) in lung cancer sections using immunohistochemical staining.

resultsA number of genes were identified as candidate immunohistochemical markers with high sensitivity and specificity in distinguishing LUAD from LUSC. Then the staining results confirmed the potentials of the six genes (MLPH, TMC5, SFTA3, DSG3, DSC3 and CALML3) in distinguishing LUAD from LUSC, and their sensitivity and specificity were not less than many commonly used markers.

conclusionsThe results revealed that the six genes (MLPH, TMC5, SFTA3, DSG3, DSC3 and CALML3) might be suitable markers in distinguishing LUAD from LUSC, and also validated the feasibility of our methods for identification of candidate markers from high-throughput data.

Indexed as

immunohistochemical markerLung cancerreceiver operating characteristic (ROC) curve analysisThe Cancer Genome Atlas (TCGA)

Identifiers

PMID26380766
PMCPMC4561256
OpenAlexW1916274949

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.