Evidence map›Paper›PMID 26380342›Full record

ArticleOpen forum infectious diseases2015

Antibody-Dependent Cellular Inhibition Is Associated With Reduced Risk Against Febrile Malaria in a Longitudinal Cohort Study Involving Ghanaian Children.

Regis W Tiendrebeogo, Bright Adu, Susheel K Singh, Morten H Dziegiel, Issa Nébié, Sodiomon B Sirima, Michael Christiansen, Daniel Dodoo, Michael Theisen

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Regis W TiendrebeogoDepartment of Clinical Biochemistry, Immunology and Genetics , Statens Serum Institut , Copenhagen ; Centre for Medical Parasitology at Department of International Health, Immunology, Microbiology, and Department of Infectious Diseases , Rigshospitalet, University of Copenhagen.
Bright AduDepartment of Clinical Biochemistry, Immunology and Genetics , Statens Serum Institut , Copenhagen ; Centre for Medical Parasitology at Department of International Health, Immunology, Microbiology, and Department of Infectious Diseases , Rigshospitalet, University of Copenhagen.
Susheel K SinghDepartment of Clinical Biochemistry, Immunology and Genetics , Statens Serum Institut , Copenhagen ; Centre for Medical Parasitology at Department of International Health, Immunology, Microbiology, and Department of Infectious Diseases , Rigshospitalet, University of Copenhagen.
Morten H DziegielBlood Bank KI 2034, Copenhagen University Hospital , Denmark.
Issa NébiéCentre National de Recherche et de Formation sur le Paludisme , Ouagadougou , Burkina Faso.
Sodiomon B SirimaCentre National de Recherche et de Formation sur le Paludisme , Ouagadougou , Burkina Faso.
Michael ChristiansenDepartment of Clinical Biochemistry, Immunology and Genetics , Statens Serum Institut , Copenhagen.
Daniel DodooNoguchi Memorial Institute for Medical Research , University of Ghana , Legon.
Michael TheisenDepartment of Clinical Biochemistry, Immunology and Genetics , Statens Serum Institut , Copenhagen ; Centre for Medical Parasitology at Department of International Health, Immunology, Microbiology, and Department of Infectious Diseases , Rigshospitalet, University of Copenhagen.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The antibody-dependent respiratory burst and opsonic phagocytosis assays have been associated with protection against malaria; however, other mechanisms may also be involved. The antibody-dependent cellular inhibition (ADCI) assay is yet to be correlated with protection in longitudinal cohort studies (LCS). We investigated the relationship between ADCI activity of immunoglobulin G before malaria season and risk of malaria in a LCS involving Ghanaian children. High ADCI activity was significantly associated with reduced risk against malaria. Findings here suggest a potential usefulness of the ADCI assay as a correlate of protection to guide malaria vaccine studies.

Indexed as

antibody-dependent cellular inhibitionchildrenlongitudinal cohort studymalariamonocytesPlasmodium falciparum

Identifiers

PMID26380342
PMCPMC4567085

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.