Evidence map›Paper›PMID 26380339›Full record

ArticleOpen forum infectious diseases2015

A Human Immunodeficiency Virus Controller With a Large Population of CD4(+)CD8(+) Double-Positive T Cells.

Christine M Durand, Robert W Buckheit, Maria Salgado, Christopher W Pohlmeyer, Victoria E Walker-Sperling, Robert W Hegarty, Richard F Ambinder, Joel N Blankson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Legend or Truth: Mature CD4Biomedicines · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christine M DurandDepartments of Medicine ; Oncology , Johns Hopkins School of Medicine , Baltimore, Maryland.
Robert W BuckheitDepartments of Medicine.
Maria SalgadoDepartments of Medicine.
Christopher W PohlmeyerDepartments of Medicine.
Victoria E Walker-SperlingDepartments of Medicine.
Robert W HegartyDepartments of Medicine.
Richard F AmbinderDepartments of Medicine ; Oncology , Johns Hopkins School of Medicine , Baltimore, Maryland.
Joel N BlanksonDepartments of Medicine.

Funding

BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
Training Program in Cellular and Molecular MedicineT32GM008752 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI RAO, RAJINI · 2000 to 2019
$11.7M
CELLULAR &MOLECULAR MECH OF INFLAMMATORY REACTIONST32AI007247 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Joel L Pomerantz · 1985 to 2026
$10.2M
NIAID NIH HHS T32 AI007247NIGMS NIH HHS T32 GM007445NIGMS NIH HHS T32 GM008752
6 · The paper itself

Abstract

Human immunodeficiency virus (HIV) controllers are patients who control viral replication without antiretroviral therapy. We present the case of an HIV controller who had CD4 and CD8 coexpressed on 40% of his T cells. Although a recent study found that double-positive T cells had superior antiviral capacity in HIV-1 controllers, in this case, the CD4(+)CD8(+) T cells did not have strong antiviral activity.

Indexed as

AIDSdouble-positive cellselite controllersHIVHIV controllersimmune activationlong-term nonprogressorsviremic controllers

Identifiers

PMID26380339
PMCPMC4567082

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.