ArticleJournal of immunology research2015
Serum Calprotectin: A Potential Biomarker for Neonatal Sepsis.
Article in Journal of immunology research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Calprotectin as a diagnostic marker for sepsis: A meta-analysis.Frontiers in cellular and infection microbiology · 2022Pooled it
- The value of fecal calprotectin inFrontiers in physiology · 2022Pooled it
- Assessment of C-Reactive Protein Diagnostic Test Accuracy for Late-Onset Infection in Newborn Infants: A Systematic Review and Meta-analysis.JAMA pediatrics · 2020Pooled it
- C-reactive protein for diagnosing late-onset infection in newborn infants.The Cochrane database of systematic reviews · 2019Pooled it
- Circulating calprotectin (C-CLP) as a potential biomarker for early diagnosis of intra-abdominal infections.Updates in surgery · 2026Article
- Correlation of Serum Calprotectin with SOFA Score in Pediatric Sepsis - A Cross-sectional Pilot Study.Indian journal of pediatrics · 2024Article
- Validation of Serum Calprotectin Relative to Other Biomarkers of Infection in Febrile Infants Presenting to the Emergency Department.Antibiotics (Basel, Switzerland) · 2024Article
- Biomarkers of Neonatal Sepsis: Where We Are and Where We Are Going.Antibiotics (Basel, Switzerland) · 2023Review
- Plasma calprotectin as an indicator of need of transfer to intensive care in patients with suspected sepsis at the emergency department.BMC emergency medicine · 2023Article
- Is canine calprotectin in serum stabile after storage at low temperature?BMC veterinary research · 2022Article
- Serum Calprotectin Is a Valid Biomarker in Distinction of Bacterial Urinary Tract Infection From Viral Respiratory Illness in Children Under 3 Years of Age.Frontiers in pediatrics · 2022Article
- Association of Serum Calprotectin Concentrations with Mortality in Critically Ill and Septic Patients.Diagnostics (Basel, Switzerland) · 2020Article
- Calprotectin in inflammatory bowel disease.Clinica chimica acta; international journal of clinical chemistry · 2020Review
- Narciclasine improves outcome in sepsis among neonatal rats via inhibition of calprotectin and alleviating inflammatory responses.Scientific reports · 2020Article
- S100-Alarmins Are Essential Pilots of Postnatal Innate Immune Adaptation.Frontiers in immunology · 2020Review
- The time course of calprotectin liberation from human neutrophil granulocytes afterInnate immunity · 2019Article
- Multifarious diagnostic possibilities of the S100 protein family: predominantly in pediatrics and neonatology.World journal of pediatrics : WJP · 2018Review
- Calprotectin can play an inflammatory role in acne vulgaris.Postepy dermatologii i alergologii · 2018Article
- Sepsis-Induced Immunosuppression in Neonates.Frontiers in pediatrics · 2018Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe correct diagnosis of neonatal sepsis is a relevant problem because sepsis is one of the most important causes of neonatal morbidity, mortality, and prolonged hospital stay. Calprotectin is an antimicrobial, calcium and zinc binding heterocomplex protein that could be used as a nonspecific marker for activation of granulocytes and mononuclear phagocytes. Calprotectin has been proposed for the diagnosis of inflammatory conditions. Our aim is to study serum calprotectin as a biomarker for neonatal sepsis diagnosis.
methods41 (20 females, 21 males) infants who underwent blood culture due to suspected sepsis were enrolled in the study. Serum calprotectin was measured by a commercial ELISA assay (Calprest, Eurospital, Trieste, Italy). Statistical analysis was performed using the statistical software package Stata 13.1 (Stata Corporation, College Station, Texas, USA).
results8 neonates (19.51%) showed sepsis with positive culture and 33 (80.49%) showed suspected sepsis. The optimal cut-off for calprotectin is 2.2 μg/mL with a sensitivity of 62.5% and a specificity of 69.7%.
conclusionsCalprotectin may be considered a promising early, sensitive, specific marker of sepsis thanks to the importance of calprotectin in defense mechanisms and physiological functions of the immune system.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.