ArticleFrontiers in pediatrics2015
Investigation on the Factors Affecting Cronobacter sakazakii Contamination Levels in Reconstituted Powdered Infant Formula.
Article in Frontiers in pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
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Who cites it
10 citing papers in PubMed.
- Inactivation kinetics ofFrontiers in microbiology · 2026Article
- Emerging microbial risks: Cronobacter sakazakii in powdered infant formula for infants under six months of age in Ethiopia.BMC microbiology · 2025Article
- Global and regional prevalence of Cronobacter sakazakii in powdered milk and flour.Scientific reports · 2024Article
- Review
- Foodborne pathogens in Africa: UnderstandingPublic health challenges · 2023Review
- Underestimated Risks of Infantile Infectious Disease from the Caregiver's Typical Handling Practices of Infant Formula.Scientific reports · 2019Article
- Article
- Multiplexed Lateral Flow Test for Detection and Differentiation ofFrontiers in microbiology · 2017Article
- Variability in Cell Response of Cronobacter sakazakii after Mild-Heat Treatments and Its Impact on Food Safety.Frontiers in microbiology · 2016Article
- The Roles of Epidemiologists, Laboratorians, and Public Health Agencies in Preventing Invasive Cronobacter Infection.Frontiers in pediatrics · 2015Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCertain strains of Cronobacter sakazakii can cause serious invasive infections in children, mainly those <2 months old and fed with powdered infant formula (PIF). The infectious dose of C. sakazakii is unknown but evidence suggests that it is approximately 1000 colony forming units (CFU). PIF is currently considered safe if its end-product C. sakazakii level is <1 CFU/g. In this study, we determined the lag time, generation time (GT), and growth rate of five pooled C. sakazakii isolates to evaluate the factors affecting contamination levels in reconstituted PIF.
methods1.71 log CFU/ml of C. sakazakii were inoculated into 100 and 3000 ml of reconstituted PIF and incubated at 22 and 35°C. Growth was evaluated over a 24-h period. ComBase was used for modeling.
resultsIn 3000 ml, the growth rate was 0.45 ± 0.02 log CFU/h with a lag phase of 3 ± 0.05 h and GT of 0.67 h at 22°C, while the growth rate was 0.73 ± 0.01 log CFU/h with a lag phase of 0.45 ± 0.03 h and GT of 0.41 h at 35° C.
conclusionCronobacter sakazakii grows rapidly in reconstituted PIF, especially at 35° C.
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