ReviewFrontiers in oncology2015
Nicotine: Carcinogenicity and Effects on Response to Cancer Treatment - A Review.
Review in Frontiers in oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 147 citations in OpenAlex.
- Impact of Survey Item Wording and Response Options on Prevalence of Beliefs About Nicotine Causing Cancer: A Randomized Survey Experiment.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Trial
- Inverse Association Between Regional Availability of Board-Certified Fellows of the Japan Gastroenterological Endoscopy Society and Colorectal Cancer Mortality in Japan: An Ecological Analysis.JGH open : an open access journal of gastroenterology and hepatology · 2026Article
- Risk Assessment Models for Heated Tobacco Products.Risk analysis : an official publication of the Society for Risk Analysis · 2026Article
- Effects of Nicotine on Urinary Bladder Carcinogenesis.Pathology international · 2026Review
- A nine-gene nicotine-metabolism signature predicts prognosis and characterizes the immune landscape in colon adenocarcinoma.Journal of gastrointestinal oncology · 2026Article
- Nicotine: evolution, dependence, and the path to total quit: redefining cessation in a changing nicotine landscape.Frontiers in public health · 2026Review
- Healthcare providers' beliefs about the health effects of nicotine and electronic cigarettes.PloS one · 2026Article
- What Is the Evidence for "Resistant Smokers?"American journal of respiratory and critical care medicine · 2025Article
- The Biological and Prognostic Implications of the Nicotinic Acetylcholine Receptor α3, α5, and α7 Subunits in Oral Squamous Cell Carcinoma.Cancer medicine · 2025Article
- Nicotine from a Different Angle: Biological Effects from a Psychoneuroimmunological Perspective.International journal of molecular sciences · 2025Review
- The impact of smoking on lung cancer patients.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Long COVID - a critical disruption of cholinergic neurotransmission?Bioelectronic medicine · 2025Review
- Cell signaling and epigenetic regulation of nicotine-induced carcinogenesis.Environmental pollution (Barking, Essex : 1987) · 2024Review
- The cardio-oncology continuum: Bridging the gap between cancer and cardiovascular care.Global cardiology science & practice · 2024Review
- Identification and validation of the nicotine metabolism-related signature of bladder cancer by bioinformatics and machine learning.Frontiers in immunology · 2024Article
- Nicotine or marijuana vaping exposure during pregnancy and altered immune responses in offspring.Journal of environmental exposure assessment · 2024Article
- E-cigarette exposure disrupts antitumor immunity and promotes metastasis.Frontiers in immunology · 2024Article
- A systematic review of preclinical studies evaluating the association between nicotine and the initiation and progression of cancer.Annals of translational medicine · 2023Review
- E-Cigarettes and Associated Health Risks: An Update on Cancer Potential.Advances in respiratory medicine · 2023Review
- Inflammation-Related Immune-Modulatory SLURP1 Prevents the Proliferation of Human Colon Cancer Cells, and Its Delivery byPharmaceutics · 2023Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tobacco use is considered the single most important man-made cause of cancer that can be avoided. The evidence that nicotine is involved in cancer development is reviewed and discussed in this paper. Both tobacco smoke and tobacco products for oral use contain a number of carcinogenic substances, such as polycyclic hydrocarbons and tobacco-specific N-nitrosamines (TSNA), which undoubtedly contribute to tobacco related cancer. Recent studies have shown that nicotine can affect several important steps in the development of cancer, and suggest that it may cause aggravation and recurrence of the disease. TSNA may be formed from nicotine in the body. The role of nicotine as the major addictive component of tobacco products may have distracted our attention from toxicological effects on cell growth, angiogenesis, and tumor malignancy. Effects on cancer disease are important aspects in the evaluation of possible long-term effects from sources of nicotine, such as e-cigarettes and products for nicotine replacement therapy, which both have a potential for life-long use.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.