ArticleNeural plasticity2015
Muscarinic ACh Receptors Contribute to Aversive Olfactory Learning in Drosophila.
Article in Neural plasticity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Transcriptomic investigation of agonistic behaviors of boxer shrimps (Stenopus species): insights into the potential neural signaling roles of dopamine and acetylcholine.BMC genomics · 2026Article
- Oxygen-dependent regulation of serotonin receptoriScience · 2025Article
- Cellular Activity Modulation Mediated by Near Infrared-Irradiated Polydopamine Nanoparticles: In Vitro and Ex Vivo Investigation.ACS nano · 2025Article
- Cell-specific genetic expression profile of antennal glia in Drosophila reveals candidate genes in neuron-glia interactions.Scientific reports · 2025Article
- Article
- Sensory encoding and memory in the mushroom body: signals, noise, and variability.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Article
- Polygenic adaptation to overnutrition reveals a role for cholinergic signaling in longevity.bioRxiv : the preprint server for biology · 2023Article
- Localization of muscarinic acetylcholine receptor-dependent rhythm-generating modules in theJournal of neurophysiology · 2022Article
- Article
- The Neuromodulatory Basis of Aggression: Lessons From the Humble Fruit Fly.Frontiers in behavioral neuroscience · 2022Review
- Nicotine suppresses Parkinson's disease like phenotypes induced by Synphilin-1 overexpression in Drosophila melanogaster by increasing tyrosine hydroxylase and dopamine levels.Scientific reports · 2021Article
- Tyramine induces dynamic RNP granule remodeling and translation activation in the Drosophila brain.eLife · 2021Article
- Cellular and circuit mechanisms of olfactory associative learning inJournal of neurogenetics · 2020Review
- The Neurotransmitters Involved inFrontiers in behavioral neuroscience · 2020Review
- Characterization of an A-Type Muscarinic Acetylcholine Receptor and Its Possible Non-neuronal Role in the Oriental Armyworm,Frontiers in physiology · 2020Article
- Inhibitory muscarinic acetylcholine receptors enhance aversive olfactory learning in adulteLife · 2019Article
- Olfactory Bulb Muscarinic Acetylcholine Type 1 Receptors Are Required for Acquisition of Olfactory Fear Learning.Frontiers in behavioral neuroscience · 2019Article
- Electrochemical Measurements of Acetylcholine-Stimulated Dopamine Release in Adult Drosophila melanogaster Brains.Analytical chemistry · 2018Article
- Developmental experience-dependent plasticity in the first synapse of the Drosophila olfactory circuit.Journal of neurophysiology · 2016Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The most studied form of associative learning in Drosophila consists in pairing an odorant, the conditioned stimulus (CS), with an unconditioned stimulus (US). The timely arrival of the CS and US information to a specific Drosophila brain association region, the mushroom bodies (MB), can induce new olfactory memories. Thus, the MB is considered a coincidence detector. It has been shown that olfactory information is conveyed to the MB through cholinergic inputs that activate acetylcholine (ACh) receptors, while the US is encoded by biogenic amine (BA) systems. In recent years, we have advanced our understanding on the specific neural BA pathways and receptors involved in olfactory learning and memory. However, little information exists on the contribution of cholinergic receptors to this process. Here we evaluate for the first time the proposition that, as in mammals, muscarinic ACh receptors (mAChRs) contribute to memory formation in Drosophila. Our results show that pharmacological and genetic blockade of mAChRs in MB disrupts olfactory aversive memory in larvae. This effect is not explained by an alteration in the ability of animals to respond to odorants or to execute motor programs. These results show that mAChRs in MB contribute to generating olfactory memories in Drosophila.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.