Evidence map›Paper›PMID 26380095›Full record

ArticleBMJ open diabetes research & care2015

Inpatient HbA1c testing: a prospective observational study.

Natalie Nanayakkara, Hang Nguyen, Leonid Churilov, Alvin Kong, Nyuk Pang, Graeme K Hart, Elizabeth Owen-Jones, Jennifer White, Jane Ross, Victoria Stevenson and 8 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open diabetes research & care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

  1. American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022
    Guideline
  2. Pooled it
  3. Trial
  4. Article
  5. Review
  6. Review
  7. Review
  8. Observational
  9. Review
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  11. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Natalie NanayakkaraDepartment of Endocrinology , Austin Health ,  Melbourne, Victoria , Australia.
Hang NguyenDepartment of General Medicine , Austin Health , Heidelberg, Victoria , Australia.
Leonid ChurilovThe Florey Institute of Neuroscience & Mental Health , Melbourne, Victoria , Australia.
Alvin KongDepartment of Endocrinology , Austin Health ,  Melbourne, Victoria , Australia.
Nyuk PangDepartment of Endocrinology , Austin Health ,  Melbourne, Victoria , Australia.
Graeme K HartDepartment of Intensive Care , Austin Health , Heidelberg, Victoria , Australia.
Elizabeth Owen-JonesAustin Centre for Applied Clinical Informatics, Austin Health , Heidelberg, Victoria , Australia.
Jennifer WhiteAustin Centre for Applied Clinical Informatics, Austin Health , Heidelberg, Victoria , Australia.
Jane RossAustin Centre for Applied Clinical Informatics, Austin Health , Heidelberg, Victoria , Australia.
Victoria StevensonDepartment of Endocrinology , Austin Health ,  Melbourne, Victoria , Australia.
Rinaldo BellomoDepartment of Intensive Care , Austin Health , Heidelberg, Victoria , Australia.
Que LamDepartment of Pathology , Austin Hospital , Heidelberg, Victoria , Australia.
Nicholas CrinisDepartment of Pathology , Austin Hospital , Heidelberg, Victoria , Australia.
Raymond RobbinsDepartment of Administrative Informatics , Austin Hospital , Melbourne, Victoria , Australia.
Doug JohnsonDepartment of General Medicine , Austin Health , Heidelberg, Victoria , Australia.
Scott T BakerDepartment of Endocrinology , Austin Health ,  Melbourne, Victoria , Australia ; Department of General Medicine , Austin Health , Heidelberg, Victoria , Australia.
Jeffrey D ZajacDepartment of Endocrinology , Austin Health ,  Melbourne, Victoria , Australia ; University of Melbourne (Austin Health) , Parkville, Victoria , Australia.
Elif I EkinciDepartment of Endocrinology , Austin Health ,  Melbourne, Victoria , Australia ; University of Melbourne (Austin Health) , Parkville, Victoria , Australia ; Menzies School of Health Research , Darwin, Victoria , Australia.
Austin Health · AUAustin Hospital · AUFlorey Institute of Neuroscience and Mental Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo use admission inpatient glycated hemoglobin (HbA1c) testing to help investigate the prevalence of unrecognized diabetes, the cumulative prevalence of unrecognized and known diabetes, and the prevalence of poor glycemic control in both. Moreover, we aimed to determine the 6-month outcomes for these patients. Finally, we aimed to assess the independent association of diabetes with these outcomes. RESEARCH DESIGN AND

methodsProspective observational cohort study conducted in a tertiary hospital in Melbourne, Australia. PATIENTS: A cohort of 5082 inpatients ≥54 years admitted between July 2013 and January 2014 underwent HbA1c measurement. A previous diagnosis of diabetes was obtained from the hospital medical record. Patient follow-up was extended to 6 months.

resultsThe prevalence of diabetes (known and unrecognized) was 34%. In particular, we identified that unrecognized but HbA1c-confirmed diabetes in 271 (5%, 95% CI 4.7% to 6.0%) patients, previously known diabetes in 1452 (29%, 95% CI 27.3% to 29.8%) patients; no diabetes in 3359 (66%, 95% CI 64.8-67.4%) patients. Overall 17% (95% CI 15.3% to 18.9%) of patients with an HbA1c of >6.5% had an HbA1c ≥8.5%. After adjusting for age, gender, Charlson Index score, estimated glomerular filtration rate, and hemoglobin levels, with admission unit treated as a random effect, patients with previously known diabetes had lower 6-month mortality (OR 0.69, 95% CI 0.56 to 0.87, p=0.001). However, there were no significant differences in proportions of intensive care unit admission, mechanical ventilation or readmission within 6 months between the 3 groups.

conclusionsApproximately one-third of all inpatients ≥54 years of age admitted to hospital have diabetes of which about 1 in 6 was previously unrecognized. Moreover, poor glycemic control was common. Proportions of intensive care unit admission, mechanical ventilation, or readmission were similar between the groups. Finally, diabetes was independently associated with lower 6-month mortality.

Indexed as

HbA1cHospital CareQuality ImprovementTesting

Identifiers

PMID26380095
PMCPMC4567658
OpenAlexW2287953383

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.