ArticleCancer & metabolism2015
(13)C-labeled biochemical probes for the study of cancer metabolism with dynamic nuclear polarization-enhanced magnetic resonance imaging.
Article in Cancer & metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Progress in the application of molecular imaging technology in immunological tolerance and immune metabolism visualization research.Frontiers in immunology · 2025Review
- Raman micro-spectroscopy reveals the spatial distribution of fumarate in cells and tissues.Nature communications · 2024Article
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- Multi-sample/multi-nucleus parallel polarization and monitoring enabled by a fluid path technology compatible cryogenic probe for dissolution dynamic nuclear polarization.Scientific reports · 2023Article
- Metabolic response to radiation therapy in cancer.Molecular carcinogenesis · 2022Review
- HyperpolarizedAntioxidants & redox signaling · 2022Review
- Measuring Glycolytic Activity with Hyperpolarized [Metabolites · 2021Article
- Hyperpolarized Magnetic Resonance and Artificial Intelligence: Frontiers of Imaging in Pancreatic Cancer.JMIR medical informatics · 2021Review
- Tumor Microenvironment Biosensors for Hyperpolarized Carbon-13 Magnetic Resonance Spectroscopy.Molecular imaging and biology · 2021Review
- Deuterated water imaging of the rat brain following metabolism of [Magnetic resonance in medicine · 2021Article
- Biomedical Applications of the Dynamic Nuclear Polarization and Parahydrogen Induced Polarization Techniques for HyperpolarizedMagnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2021Review
- Modeling hyperpolarized lactate signal dynamics in cells, patient-derived tissue slice cultures and murine models.NMR in biomedicine · 2021Article
- Recent Metabolomics Analysis in Tumor Metabolism Reprogramming.Frontiers in molecular biosciences · 2021Review
- Probing carbohydrate metabolism using hyperpolarizedNMR in biomedicine · 2019Review
- Focus on the glycerophosphocholine pathway in choline phospholipid metabolism of cancer.NMR in biomedicine · 2019Review
- The Role of Tumor Oxygenation Tested by Magnetic Resonance Imaging (MRI) in Prostate Cancer Grading.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- HyperpolarizedNeoplasia (New York, N.Y.) · 2019Review
- Article
- Imaging Cancer Metabolism.Biomolecules & therapeutics · 2018Review
- In Vivo Imaging of Glutamine Metabolism to the Oncometabolite 2-Hydroxyglutarate in IDH1/2 Mutant Tumors.Cell metabolism · 2017Article
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2 authors.
Funding
Abstract
In recent years, advances in metabolic imaging have become dependable tools for the diagnosis and treatment assessment in cancer. Dynamic nuclear polarization (DNP) has recently emerged as a promising technology in hyperpolarized (HP) magnetic resonance imaging (MRI) and has reached clinical relevance with the successful visualization of [1-(13)C] pyruvate as a molecular imaging probe in human prostate cancer. This review focuses on introducing representative compounds relevant to metabolism that are characteristic of cancer tissue: aerobic glycolysis and pyruvate metabolism, glutamine addiction and glutamine/glutamate metabolism, and the redox state and ascorbate/dehydroascorbate metabolism. In addition, a brief introduction of probes that can be used to trace necrosis, pH changes, and other pathways relevant to cancer is presented to demonstrate the potential that HP MRI has to revolutionize the use of molecular imaging for diagnosis and assessment of treatments in cancer.
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