ArticleInternational journal of clinical and experimental medicine2015
Autophagy involving age-related cognitive behavior and hippocampus injury is modulated by different caloric intake in mice.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Regulation of autophagy-mediated pathways by diet, physical activity, and sleep in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Autolysosomal Dysfunction in Obesity-induced Metabolic Inflammation and Related Disorders.Current obesity reports · 2025Review
- Does dietary nitrate boost the effects of caloric restriction on brain health? Potential physiological mechanisms and implications for future research.Nutrition & metabolism · 2023Review
- Effects of Caloric Restriction on Spatial Object Recognition Memory, Hippocampal Neuron Loss and Neuroinflammation in Aged Rats.Nutrients · 2023Article
- Caloric Restriction Can Ameliorate Postoperative Cognitive Dysfunction by Upregulating the Expression of Sirt1, MeCP2 and BDNF in the Hippocampal CA1 Region of Aged C57BL/6 Mice.Brain sciences · 2023Article
- Dapagliflozin as an autophagic enhancer via LKB1/AMPK/SIRT1 pathway in ovariectomized/D-galactose Alzheimer's rat model.Inflammopharmacology · 2022Article
- mTOR Complex 1 Content and Regulation Is Adapted to Animal Longevity.International journal of molecular sciences · 2022Review
- Icariin improves brain function decline in aging rats by enhancing neuronal autophagy through the AMPK/mTOR/ULK1 pathway.Pharmaceutical biology · 2021Article
- Progress in the Mechanism of Autophagy and Traditional Chinese Medicine Herb Involved in Dementia.Frontiers in pharmacology · 2021Review
- Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques.Molecular neurodegeneration · 2020Article
- Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner.Nature communications · 2019Article
- Influence of Normal Aging on Brain Autophagy: A Complex Scenario.Frontiers in aging neuroscience · 2019Review
- Reducing CXCR4 Resulted in Impairing Proliferation and Promoting Aging.The journal of nutrition, health & aging · 2018Article
- Interplay Between the Gut-Brain Axis, Obesity and Cognitive Function.Frontiers in neuroscience · 2018Review
- ER stress and impaired autophagy flux in neuronal degeneration and brain injury.Ageing research reviews · 2017Review
- Unified theory of Alzheimer's disease (UTAD): implications for prevention and curative therapy.Journal of molecular psychiatry · 2016Review
- Mammalian Target of Rapamycin: Its Role in Early Neural Development and in Adult and Aged Brain Function.Frontiers in cellular neuroscience · 2016Review
- Comparison of the effects of resveratrol and caloric restriction on learning and memory in juvenile C57BL/6J mice.Iranian journal of basic medical sciences · 2015Article
- Early Shifts of Brain Metabolism by Caloric Restriction Preserve White Matter Integrity and Long-Term Memory in Aging Mice.Frontiers in aging neuroscience · 2015Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies indicated that different caloric intake may influence neuronal function. Excessive caloric intake associated with accelerated aging of the brain and increased the risk of neurodegenerative disorders. And low caloric intake (caloric restriction, CR) could delay aging, and protect the central nervous system from neurodegenerative disorders. The underlying mechanisms remain poorly understood. In this study, thirty six-week-old male C57/BL male mice were randomly divided into three different dietary groups: normal control (NC) group (fed standard diet), CR group (fed low-caloric diet) and high-calorie (HC) group (fed high-caloric diet). After 10 months, spatial memory ability was determined by Morris water maze. Pathological changes of the hippocampus cells were detected with HE and Nissl staining. The expression of proteins involved in autophagy in the hippocampus was determined by immunofluorescence and Western blot. The result of Morris water maze showed that the learning and memory capacity significantly increased in the CR group, and significantly decreased in the HC group. HE and Nissl staining showed cells damaged obviously in the HC group. The expression of mTOR and p62 was increased in the HC group, and decreased in the CR group. The expression of Beclin1, LC3 and cathepsin B was decreased in the HC group, and increased in the CR group. Our findings demonstrate that long-term high caloric intake is a risk factor that can significantly contribute to the development of neurological disease via suppressing autophagy, and CR may prevent age-related learning ability impairment via activating autophagy in mice.
Indexed as
Identifiers
26380026PMC4565409W2401894323What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.