Evidence map›Paper›PMID 26380014›Full record

ArticleInternational journal of clinical and experimental medicine2015

Platelet to lymphocyte ratio plays an important role in prostate cancer's diagnosis and prognosis.

Feng Li, Haibo Hu, Shuo Gu, Xin Chen, Qing Sun

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Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  13. Diagnostic Value of Platelet-To-Lymphocyte Ratio in Prostate Cancer.Open access Macedonian journal of medical sciences · 2019
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  18. The Lymphocyte-Monocyte Ratio and the Platelet-Lymphocyte Ratio at Diagnosis as Independent Prognostic Factors in Primary Gastrointestinal Diffuse Large B Cell Lymphoma.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Feng LiDepartment of Anesthesiology, The First People's Hospital of Yancheng Yancheng 224006, Jiangsu Province, China.
Haibo HuDepartment of Cardiothoracic Surgery, The Affiliated Huai'an Hospital of Xuzhou Medical College Huai'an 223002, Jiangsu Province, China.
Shuo GuDepartment of Urology, Huai'an First People's Hospital, Nanjing Medical University Huai'an 223300, Jiangsu Province, China.
Xin ChenDepartment of Anesthesiology, Huai'an First People's Hospital, Nanjing Medical University Huai'an 223300, Jiangsu Province, China.
Qing SunDepartment of Urology, Huai'an First People's Hospital, Nanjing Medical University Huai'an 223300, Jiangsu Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the platelet to lymphocyte ratio (PLR) in normal people, benign prostatic hyperplasia (BPH) patients and prostate cancer (PCA) patients, and to explore the prognostic role of PLR in PCA.

methods155 normal people, 168 BPH patients and 103 PCA patients were enrolled. PCA patients were divided into PLR low value group (PLR<150) and PLR high value group (PLR≥150), and the difference of patients' clinical characteristics between high value group and low value group was comparative studied.

resultsThe differences of PLR among normal people, BPH patients and PCA patients were statistically significant. In addition, platelet counts, neutrophil counts, PSA level, LDH level, AKP level, CRP level and alkaline phosphatase level were also significantly increased in PLR high value group, while the hemoglobin level was decreased. Besides, serious events such as coma during hospitalization were also more likely to appear in PLR high value group. PCA patients had an average follow-up of 3 years, and a total of 25 cases of patients died, including 11 (16.4%) cases in the PLR low value group, and 14 (38.9%) cases in PLR high value group with. Three years survival rate of patients in high value group was significantly reduced. Additionally, PLR was a possible risk factor associated with mortality, and an independent predictor of all-cause mortality during follow-up.

conclusionPLR is significantly increased in PCA patients, and it is an independent predictor of 3-year mortality in PCA patients.

Indexed as

clinical significancemortalityPlatelet to lymphocyte ratioprognosisprostate cancer

Identifiers

PMID26380014
PMCPMC4565397

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.