ArticleInternational journal of clinical and experimental medicine2015
Association between polymorphisms in APE1 and XRCC1 and the risk of gastric cancer in Korean population.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Haplotypes of single cancer driver genes and their local ancestry in a highly admixed long-lived population of Northeast Brazil.Genetics and molecular biology · 2022Article
- Associations between polymorphisms in genes of base excision repair pathway and lung cancer risk.Translational cancer research · 2020Article
- Association ofClinical and experimental gastroenterology · 2020Article
- rs1760944 Polymorphism in the APE1 Region is Associated with Risk and Prognosis of Osteosarcoma in the Chinese Han Population.Scientific reports · 2017Article
- Article
- Association of DNA repair and xenobiotic pathway gene polymorphisms with genetic susceptibility to gastric cancer patients in West Bengal, India.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The DNA repair system plays a pivotal role in maintaining genomic integrity and protection against mutations that could lead to cancer development. The aim of this study was to explore the association between common polymorphisms of DNA repair genes, APE1 (rs1760944 and rs1130409) and XRCC1 (rs1799782, rs25487, and rs25489), and gastric cancer (GC) risk in the Korean population. We conducted a case-control study of 368 GC patients and 398 controls by using TaqMan genotyping assay. None of the polymorphisms was associated with the risk of GC. Further analysis showed a lack of association between APE1 and XRCC1 polymorphisms or haplotypes and the risk of GC and GC subgroups. The heterozygous CT genotype of XRCC1 rs25487 was related to 1.94 times increased risk of lymph node metastasis (LNM) in diffuse type GC compared to the XRCC1 rs25487 CC genotype (adjusted OR = 1.94, 95% CI = 1.06-3.53, P = 0.031) after adjusting for gender and age, whereas the remaining polymorphisms showed no association with GC or GC subgroups. This result suggests that genetic variation of XRCC1 rs25487 could be a risk factor for LNM in diffuse type of GC in the Korean population.
Indexed as
Identifiers
26379967PMC4565350W2400983475What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.