Prothrombin C20209T mutation in deep vein thrombosis: a case report.

Mariela Muñoz, Cristian Vilos, Mario Cantín

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In one paragraph

Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 81% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Mariela MuñozSchool of Medical Technology, Faculty of Health Sciences, Universidad Santo Tomás Temuco, Chile ; Fellow Researcher, Universidad Científica del Sur Lima, Perú

Cristian VilosCenter for Integrative Medicine and Innovative Science (CIMIS), Universidad Andres Bello Facultad de Medicina, Santiago, Chile ; Center for the Development of Nanoscience and Nanotechnology CEDENNA FB0807 Santiago, Chile.

Mario CantínCIMA Research Group, Faculty of Dentistry, Universidad de La Frontera Temuco, Chile ; Doctoral Program in Morphological Sciences, CEMyQ, Faculty of Medicine, Universidad de La Frontera Temuco, Chile ; Center of Research in Biomedical Sciences, Universidad Autónoma de Chile Temuco, Chile.

Universidad Santo Tomás · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thrombophilias is a recognized risk factor for thrombotic events. The prothrombin variant G20210A gene mutation has been commonly examined using polymerase chain reaction (PCR). Currently, in many clinical laboratories, performing the PCR in real-time technique, which, in addition to identifying the G20210A mutation, makes possible the detection of other mutations in the 3'UTR of the prothrombin gene by melting curve analysis, due to the ability of this analysis to be amplicon-dependent (e.g., C20209T, C20221T and A20218G). We report the first case in Chile that describes the atypical prothrombin C20209T mutation, in a 50-year-old male patient diagnosed with deep vein thrombosis in the lower limb and family history of thrombophilia. In the literature, there are few studies of the prevalence and functionality of this mutation; its association with thrombotic events is controversial.

Indexed as

3’Untranslated regionC20209Tmutationprothrombinthrombophilia

Identifiers

PMID26379928

PMCPMC4565311

OpenAlexW2414329338

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.