ArticleInternational journal of clinical and experimental medicine2015
Gender dependent association of 25-hydroxyvitamin D and circulating leptin in saudi subjects: influence of dyslipidemia.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
6 authors at 2 institutions in 2 countries.
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Abstract
BACKGROUND AND
objectiveLeptin and vitamin D play an important role in obesity development and metabolic effects; however, the association between leptin and vitamin D is not well studied in Saudi subjects. We aimed to examine gender dependent association between serum leptin and 25-OH-VitD in adult Saudi subjects. SUBJECTS AND
methodsFor this cross-sectional study in a cohort of 259 Saudi adults (100 male, age: 46.4 ± 0.9 yr [mean ± SD]; BMI: 27.8 ± 0.5 Kg/m(2)) and (159 female, age 46.5 ± 0.7 [mean ± SD]; BMI: 28.4 ± 0.4 Kg/m(2)) anthropometrics, fasting bloods, and biochemical data were collected. Serum leptin and 25-hydroxyvitamin D (vitamin D or 25-OH-VitD) were quantified using an enzyme-linked immunosorbent assay.
resultsCirculating leptin and vitamin D levels were significantly higher in females compared to male (P<0.001 and P<0.01 respectively). Visceral adiposity index (VAI), triglycerides and total cholesterol were significantly higher (P<0.05, P<0.001, and P<0.05, respectively) while HDL-cholesterol were lower (P<0.001) in male compared to female subjects. In males, vitamin D levels were positively associated with leptin (r = 0.196, P<0.05).
conclusionVitamin D was positively associated with serum leptin in male Saudi subjects. Additionally, male subjects were found to be dyslipidemic, which might be a responsible factor for this discordant association between vitamin D and leptin in Saudi population.
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Identifiers
26379918PMC4565301W2419586936What OpenQuestion holds
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