ArticleInternational journal of clinical and experimental medicine2015
Topical use of olive oil preparation to prevent radiodermatitis: results of a prospective study in nasopharyngeal carcinoma patients.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05285943 (A Comparative Study Between Topical Betamethasone Cream or Topical Olive Oil Cream in Prophylaxis Against Acute Radiodermatitis in Breast Cancer Patients.), which is not on this map. Cited by 15 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Comparative Study Between Topical Betamethasone Cream or Topical Olive Oil Cream in Prophylaxis Against Acute Radiodermatitis in Breast Cancer Patients.
Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Natural and miscellaneous agents for the prevention of acute radiation dermatitis: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Pooled it
- Use of trolamine to prevent and treat acute radiation dermatitis: a systematic review and meta-analysis.Revista latino-americana de enfermagem · 2018Pooled it
- Topical interventions to prevent acute radiation dermatitis in head and neck cancer patients: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Pooled it
- Evidence summary on non-pharmacological interventions of the radiation dermatitis in patients with head and neck cancer.Asia-Pacific journal of oncology nursing · 2026Review
- Radiomitigators: Breakthroughs in Post-Radiation Recovery.Antioxidants (Basel, Switzerland) · 2026Review
- Systematic review of the tools and outcomes for the assessment of acute radiation dermatitis severity.Clinical and translational radiation oncology · 2025Review
- Bibliometric analysis and visualization of research trends in radiation dermatitis in the past twenty years.Radiation oncology (London, England) · 2025Article
- Therapeutic Potential of Hydrogen as a Radioprotective Agent for the Prevention of Radiation Dermatitis.Antioxidants (Basel, Switzerland) · 2024Article
- Evolution of radiation-induced dermatitis treatment.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024Review
- Development and Healing Process of Severe Radiodermatitis in Patients With Head and Neck Cancer Undergoing Radiotherapy: A Scoping Review.Nursing research and practice · 2024Article
- Anti-Inflammatory and Restorative Effects of Olives in Topical Application.Dermatology research and practice · 2021Review
- Topical use of Jiawei Simiao Yongan Gao to prevent radiodermatitis in patients with head and neck cancer: A retrospective cohort study.Medicine · 2020Article
- Topical treatment of radiation-induced dermatitis: current issues and potential solutions.Drugs in context · 2020Review
- Emulsion of Olive Oil and Calcium Hydroxide for the Prevention of Radiation Dermatitis in Hypofractionation Post-Mastectomy Radiotherapy: A Randomized Controlled Trial.Breast care (Basel, Switzerland) · 2019Article
- Topical Prevention of Radiation Dermatitis in Head and Neck Cancer Patients: A Network Meta-analysis.In vivo (Athens, Greece)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRadiodermatitis is a common side effect of radiotherapy. However, an effective method for the prevention of radiodermatitis has not yet been identified. The purpose of this study was to evaluate the effectiveness of topical olive oil in the prevention of acute radiodermatitis in patients with nasopharyngeal carcinoma (NPC) who were undergoing concurrent chemoradiotherapy.
methodsA prospective study was conducted in patients with NPC. The patients were randomized into the intervention (n = 47) and control (n = 47) groups. Patients in the control group were treated with a general skin care regimen (placebo), whereas patients in the intervention group were treated with olive oil thrice daily for 7 weeks during chemoradiotherapy and for two weeks thereafter. On a weekly basis for a total duration of 9 weeks, a blinded observer assessed the severity of dermatitis, which was graded from 0 to 4 according to the Radiation Therapy Oncology Group (RTOG) criteria and the Visual Analog Scale (VAS) score.
resultsMild reactions due to radiation (grades I and II) occurred in 93.6% of the intervention group and in 72.3% of the control group. Patients in the intervention group encountered significantly less severe dermatitis during chemoradiotherapy compared with patients in the control group (P < 0.01). A multivariate analysis revealed that the use of olive oil (P < 0.01) was significantly associated with a decrease in skin injuries.
conclusionsThe prophylactic use of olive oil was associated with a significant decrease in the intensity of acute dermatitis in NPC patients. The results of this trial indicate that olive oil holds promise as a safe and effective prophylactic treatment for radiodermatitis.
Indexed as
Identifiers
26379896PMC4565279W2399821799What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.