ArticleInternational journal of clinical and experimental medicine2015
Long-term action of propofol on cognitive function and hippocampal neuroapoptosis in neonatal rats.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- From neurotoxicity to neuroprotection: Rethinking GABACell biology and toxicology · 2025Review
- Mitophagy in perioperative neurocognitive disorder: mechanisms and therapeutic strategies.European journal of medical research · 2025Review
- Suberoylanilide hydroxamic acid attenuates cognitive impairment in offspring caused by maternal surgery during mid-pregnancy.PloS one · 2024Article
- Differential Susceptibility to Propofol and Ketamine in Primary Cultures of Young and Senesced Astrocytes.Anesthesiology research and practice · 2024Article
- Disturbance of Key Cellular Subproteomes upon Propofol Treatment Is Associated with Increased Permeability of the Blood-Brain Barrier.Proteomes · 2022Article
- Comparison of Recovery Profiles of Patients Undergoing Endoscopic Lumbar Discectomy under Desflurane, Propofol, or Sevoflurane Anesthesia: A Randomized, Prospective, Clinical, Comparative Study.Journal of neurosciences in rural practice · 2022Article
- Dexmedetomidine reduces propofol-induced hippocampal neuron injury by modulating the miR-377-5p/Arc pathway.BMC pharmacology & toxicology · 2022Article
- Dexmedetomidine Combined with Low-Dose Propofol Declines Learning and Memory Impairment and Neural Cell Injury in Developing Rats.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Metformin Inhibits Propofol-Induced Apoptosis of Mouse Hippocampal Neurons HT-22 Through Downregulating Cav-1.Drug design, development and therapy · 2020Article
- Hypermethylation of EFEMP1 in the Hippocampus May Be Related to the Deficit in Spatial Memory of Rat Neonates Triggered by Repeated Administration of Propofol.BioMed research international · 2020Article
- SP100B Expression Indexed Hemorrhage in Mouse Models of Cerebral Hemorrhage.Indian journal of clinical biochemistry : IJCB · 2018Article
- The interplay of BDNF-TrkB with NMDA receptor in propofol-induced cognition dysfunction : Mechanism for the effects of propofol on cognitive function.BMC anesthesiology · 2018Article
- The protective effect of the Rho-kinase inhibitor hydroxyfasudil on propofol-induced hippocampal neuron apoptosis in neonatal rats.International journal of clinical and experimental pathology · 2018Article
- Propofol Induces Apoptosis of Neurons but Not Astrocytes, Oligodendrocytes, or Neural Stem Cells in the Neonatal Mouse Hippocampus.Brain sciences · 2017Article
- Neonatal Propofol Anesthesia Changes Expression of Synaptic Plasticity Proteins and Increases Stereotypic and Anxyolitic Behavior in Adult Rats.Neurotoxicity research · 2017Article
- Propofol Exposure in Early Life Induced Developmental Impairments in the Mouse Cerebellum.Frontiers in cellular neuroscience · 2017Article
- The Fas Ligand/Fas Death Receptor Pathways Contribute to Propofol-Induced Apoptosis and Neuroinflammation in the Brain of Neonatal Rats.Neurotoxicity research · 2016Article
- Propofol exposure during late stages of pregnancy impairs learning and memory in rat offspring via the BDNF-TrkB signalling pathway.Journal of cellular and molecular medicine · 2016Article
- [Effect of propofol on apoptosis of PC12 cells under hypoxic condition and the mechanism].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Propofol is a short-acting anesthetic and generally is utilized for the induction and maintenance of anesthesia in pediatrics and adults. However, whether repeated use of propofol affects long-term cognitive function remains unclear. This study investigated the effects of propofol on cognitive function and hippocampal neuroapoptosis in neonatal rat. A total of 112 male newborn 7-day old Sprague-Dawley rats were randomly divided into 8 groups (n=14 rats per group) and intraperitoneally injected either with saline or propofol at 50, 100, and 150 mg/kg/day for 5 consecutive days. Four non-surgical groups were assigned as Con1, P50, P100, and P150. Four surgical groups were received an appendicectomy under propofol anesthesia and assigned as Con2, SP50, SP100, SP150. After 2 months raising, cognitive function, hippocampal neuroapoptosis, and intracephalic inflammatory cytokines were evaluated. There was no obvious effect on the cognitive function and neuroapoptosis after repeated use of propofol at a low dose for 5 days, whereas repeated use of propofol at a middle/high dose significantly increase the expression of apoptotic factors (caspase-3 and Bax), pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α), and impair the cognitive function. Thus, our data suggest that repeated use of propofol at a low dose may be safe during the period of brain growth spurt. Using propofol at a recommended or higher dose for anaesthesia may lead to the cognitive defects, attributed to hippocampal neuroapoptosis and the overexpression of pro-inflammatory cytokines in the brain.
Indexed as
Identifiers
26379861PMC4565244W2413288952What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.