ArticleInternational journal of clinical and experimental medicine2015
IL-21 does not involve in OVA-induced airway remodeling and chronic airway inflammation.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- T Follicular Helper Cell Subsets and the Associated Cytokine IL-21 in the Pathogenesis and Therapy of Asthma.Frontiers in immunology · 2019Review
- Small interfering RNA directed against microRNA-155 delivered by a lentiviral vector attenuates asthmatic features in a mouse model of allergic asthma.Experimental and therapeutic medicine · 2017Article
- Chronic Rhinosinusitis with Polyps Is Characterized by Increased Mucosal and Blood Th17 Effector Cytokine Producing Cells.Frontiers in physiology · 2017Article
- Evaluation of pharmacological relaxation effect of the natural product naringin onBiomedical reports · 2016Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin (IL-21) is a member of the type I cytokine family with sequence homology to IL-2, IL-4, and IL-15. IL-21 has been reported to improve symptoms of allergic rhinitis in mice. In this study we examined whether IL-21 signaling involved in allergic airway inflammation and remodeling in vivo by using ovalbumin (OVA)-induced chronic asthma model. We showed IL-21 level was increased in the serum of asthma models but not bronchoalveolar lavage fluid (BALF). Intranasal administration with recombinant mouse IL-21 or anti-IL-21 receptor (IL-21R) antibody did not affect OVA-induced chronic airway inflammation and airway remodeling in vivo and also not affect the expression of IL-13 and TGF-β in BALF. Moreover, expression of IL-13 and TGF-β was not affect by intranasal administration with recombinant mouse IL-21 or anti-IL-21R antibody. These results indicated that IL-21 signaling might not play an important role in airway inflammation and remodeling.
Indexed as
Identifiers
26379855PMC4565238What OpenQuestion holds
Registered trials
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