ArticleTheranostics2015
Assessment of Inflammation in an Acute on Chronic Model of Inflammatory Bowel Disease with Ultrasound Molecular Imaging.
Article in Theranostics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 44 citations in OpenAlex.
- Aptamer-Functionalized Microbubbles Targeted to P-selectin for Ultrasound Molecular Imaging of Murine Bowel Inflammation.Molecular imaging and biology · 2023Article
- Molecular Imaging for Early-Stage Disease Diagnosis.Advances in experimental medicine and biology · 2023Article
- Contrast Enhanced Ultrasound Molecular Imaging of Spontaneous Chronic Inflammatory Bowel Disease in an Interleukin-2 Receptor αNanomaterials (Basel, Switzerland) · 2022Article
- Intracolic ultrasound molecular imaging: a novel method for assessing colonic tumor necrosis factor-α expression in inflammatory bowel disease.Molecular medicine (Cambridge, Mass.) · 2021Article
- Mouse Models of Intestinal Fibrosis.Methods in molecular biology (Clifton, N.J.) · 2021Article
- The Application Value of Contrast-Enhanced Ultrasound in Testicular Occupied Lesions.Computational and mathematical methods in medicine · 2021Article
- Acoustic biosensors for ultrasound imaging of enzyme activity.Nature chemical biology · 2020Article
- Antibody-Based Tracers for PET/SPECT Imaging of Chronic Inflammatory Diseases.Chembiochem : a European journal of chemical biology · 2019Review
- Chronic Model of Inflammatory Bowel Disease in IL-10Theranostics · 2019Article
- The Optimized Fabrication of a Novel Nanobubble for Tumor Imaging.Frontiers in pharmacology · 2019Article
- US Molecular Imaging of Acute Ileitis: Anti-Inflammatory Treatment Response Monitored with Targeted Microbubbles in a Preclinical Model.Radiology · 2018Article
- Accelerated Clearance of Ultrasound Contrast Agents Containing Polyethylene Glycol is Associated with the Generation of Anti-Polyethylene Glycol Antibodies.Ultrasound in medicine & biology · 2018Article
- Anatomical Road Mapping Using CT and MR Enterography for Ultrasound Molecular Imaging of Small Bowel Inflammation in Swine.European radiology · 2018Article
- Contrast-Enhanced µCT for Visualizing and Evaluating Murine Intestinal Inflammation.Theranostics · 2018Article
- rSj16 Protects against DSS-Induced Colitis by Inhibiting the PPAR-α Signaling Pathway.Theranostics · 2017Article
- Optimizing ultrasound molecular imaging of secreted frizzled related protein 2 expression in angiosarcoma.PloS one · 2017Article
- Light and sound - emerging imaging techniques for inflammatory bowel disease.World journal of gastroenterology · 2016Review
- Assessment of murine colorectal cancer by micro-ultrasound using three dimensional reconstruction and non-linear contrast imaging.Molecular therapy. Methods & clinical development · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundUltrasound (US) molecular imaging has shown promise in assessing inflammation in preclinical, murine models of inflammatory bowel disease. These models, however, initiated acute inflammation on previously normal colons, in contrast to patients where acute exacerbations are often in chronically inflamed regions. In this study, we explored the potential of dual P- and E-selectin targeted US imaging for assessing acute inflammation on a murine quiescent chronic inflammatory background.
methodsChronic colitis was induced using three cycles of 4% DSS in male FVB mice. Acute inflammation was initiated 2 weeks after the final DSS cycle through rectal administration of 1% TNBS. Mice at different stages of inflammation were imaged using a small animal ultrasound system following i.v. injection of microbubbles targeted to P- and E-selectin. In vivo imaging results were correlated with ex vivo immunofluorescence and histology.
resultsInduction of acute inflammation resulted in an increase in the targeted US signal from 5.5 ± 5.1 arbitrary units (a.u.) at day 0 to 61.0 ± 45.2 a.u. (P < 0.0001) at day 1, 36.3 ± 33.1 a.u. at day 3, returning to levels similar to control at day 5. Immunofluorescence showed significant increase in the percentage of P- and E-selectin positive vessels at day 1 (P-selectin: 21.0 ± 7.1% of vessels; P < 0.05; E-selectin: 16.4 ±3.7%; P < 0.05) compared to day 0 (P-selectin: 10.3 ± 5.7%; E-selectin: 7.3 ± 7.0%).
conclusionsAcute inflammation can be accurately measured in a clinically relevant murine model of chronic IBD using ultrasound molecular imaging with a dual P- and E- selectin-targeted contrast agent.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.