ArticleFrontiers in aging neuroscience2015
The impacts of a GO-game (Chinese chess) intervention on Alzheimer disease in a Northeast Chinese population.
Article in Frontiers in aging neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Functional Therapeutic Strategies Used in Different Stages of Alzheimer's Disease-A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Psychosocial interventions for dementia in low- and middle-income countries (LMICs): a systematic review of effectiveness and implementation readiness.Aging & mental health · 2021Pooled it
- Psychometric properties of outcome measures in non-pharmacological interventions of persons with dementia in low-and middle-income countries: A systematic review.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2021Pooled it
- Pilot Randomized Controlled Trial of the GO Game Intervention on Cognitive Function.American journal of Alzheimer's disease and other dementias · 2018Trial
- Go and the Brain: Cognitive and Neural Impacts of Training.Psychiatry investigation · 2025Article
- The effect of mahjong/bridge intellectual sports on the subjective wellbeing of middle-aged and older adults: an empirical analysis from the mixed cross-section data of CHARLS in China.Frontiers in public health · 2025Article
- Are board games useful for people with dementia? A preliminary study for a non-pharmacological intervention.Frontiers in psychology · 2025Article
- Boardgames as an innovative approach to promote life skills and well-being among inmates: A scoping review protocol.PloS one · 2024Article
- Training-Specific Changes in Regional Spontaneous Neural Activity Among Professional Chinese Chess Players.Frontiers in neuroscience · 2022Article
- Leisure Activity Variety and Brain Volume Among Community-Dwelling Older Adults: Analysis of the Neuron to Environmental Impact Across Generations Study Data.Frontiers in aging neuroscience · 2021Article
- Enhanced dynamic functional connectivity (whole-brain chronnectome) in chess experts.Scientific reports · 2020Article
- A Review on Serious Games for Dementia Care in Ageing Societies.IEEE journal of translational engineering in health and medicine · 2020Article
- Chess Practice as a Protective Factor in Dementia.International journal of environmental research and public health · 2019Review
- Acute Effects of Mental Activity on Response of Serum BDNF and IGF-1 Levels in Elite and Novice Chess Players.Medicina (Kaunas, Lithuania) · 2019Article
- Differences Between High vs. Low Performance Chess Players in Heart Rate Variability During Chess Problems.Frontiers in psychology · 2019Article
- Special series on "effects of board games on health education and promotion" board games as a promising tool for health promotion: a review of recent literature.BioPsychoSocial medicine · 2019Review
- The effectiveness of intervention with board games: a systematic review.BioPsychoSocial medicine · 2019Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A GO game can enhance mental health, but its effects on Alzheimer Disease (AD) remains unknown. To address the issue, 147 AD patients were randomly assigned into control (without GO-game intervention), Short-time GO-Game Intervention (SGGI, 1 h daily) and Long-time GO-game Intervention (LGGI, 2 h daily) groups. After 6-month follow-up, the game reduced the mean score of Montgomery-Asberg Depression Rating Scales (MADRS) of 4.72 (95% CI, 0.69 to 9.12) and Hospital Anxiety and Depression Scale (HADS) of 1.75 (95% CI, 0.17-3.68), and increased the mean score of Global Assessment of Functioning (GAF) of 4.95 (95% CI, -1.37-9.18) and RAND-36 of 4.61 (95% CI, -2.75-11.32) (P < 0.05 via controls). A GO-game intervention improved 9 of 11 items of KICA-dep (Kimberley Indigenous Cognitive Assessment of Depression). Meanwhile, serum levels of brain derived neurotrophic factor (BDNF) were higher in SGGI and LGGI groups (24.02 ± 7.16 and 28.88 ± 4.12 ng/ml respectively, P = 0.051) than those in controls (17.28 ± 7.75 ng/ml) (P < 0.001). The serum levels of BDNF showed a negative relation with MADRS and a positive relation with RAND-36 (P < 0.01). A GO-game intervention ameliorates AD manifestations by up-regulating BDNF levels.
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