ArticleFrontiers in human neuroscience2015
Altered Functional Connectivity of Fusiform Gyrus in Subjects with Amnestic Mild Cognitive Impairment: A Resting-State fMRI Study.
Article in Frontiers in human neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuroimaging evidence of acupuncture in cognitive impairment following ischemic stroke: a systematic review.Frontiers in neuroscience · 2025Pooled it
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- Alexithymia and self-harm in depressed adolescents: the mediating role of resting-state functional connectivity of the ventral hippocampal-fusiform gyrus.Annals of general psychiatry · 2026Article
- Retinal vessel diameter reflects altered resting-state fMRI connectivity and cognitive performance: A community-based study.GeroScience · 2026Article
- Blind Identification of Altered Functional Subnetworks in Alzheimer's Disease Using Resting-State fMRI.Biomedical engineering and computational biology · 2026Article
- Neurite Degradation Mediates the Effect of Amyloid Deposition on Global Cognition in Asymptomatic Older Adults.medRxiv : the preprint server for health sciences · 2025Article
- Probing locus coeruleus functional network in healthy aging and its association with Alzheimer's disease biomarkers using pupillometry.Alzheimer's research & therapy · 2025Article
- Disrupted brain functional connectivity as early signature in cognitively healthy individuals with pathological CSF amyloid/tau.Communications biology · 2024Article
- Altered gyrification in chemotherapy-treated older long-term breast cancer survivors.Brain and behavior · 2024Article
- Machine Learning Model for Mild Cognitive Impairment Stage Based on Gait and MRI Images.Brain sciences · 2024Article
- Towards a multimodal neuroimaging-based risk score for mild cognitive impairment by combining clinical studies with a large (N>37000) population-based study.medRxiv : the preprint server for health sciences · 2024Article
- Hippocampal resting-state connectivity is associated with posterior-cortical cognitive impairment in Parkinson's disease.Brain and behavior · 2024Article
- Prediction of cognitive performance differences in older age from multimodal neuroimaging data.GeroScience · 2024Article
- Impact of cognition-related single nucleotide polymorphisms on brain imaging phenotype in Parkinson's disease.Neural regeneration research · 2023Article
- Neuroimaging modalities in the detection of Alzheimer's disease-associated biomarkers.Psychoradiology · 2023Review
- Disrupted topological organization of resting-state functional brain networks in cerebral small vessel disease.Human brain mapping · 2022Article
- Brain Networks Involved in Depression in Patients with Frontotemporal Dementia and Parkinson's Disease: An Exploratory Resting-State Functional Connectivity MRI Study.Diagnostics (Basel, Switzerland) · 2022Article
- Functional Network Connectivity Reveals the Brain Functional Alterations in Breast Cancer Survivors.Journal of clinical medicine · 2022Article
- Altered functional hubs and connectivity in type 2 diabetes mellitus with and without mild cognitive impairment.Frontiers in neurology · 2022Article
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9 authors.
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Abstract
Visual cognition such as face recognition requests a high degree of functional integration between distributed brain areas of a network. It has been reported that the fusiform gyrus (FG) is an important brain area involved in facial cognition; altered connectivity of FG to some other regions may lead to a deficit in visual cognition especially face recognition. However, whether functional connectivity between the FG and other brain areas changes remains unclear in the resting state in amnestic mild cognitive impairment (aMCI) subjects. Here, we employed a resting-state functional MRI (fMRI) to examine alterations in functional connectivity of left/right FG comparing aMCI patients with age-matched control subjects. Forty-eight aMCI and 38 control subjects from the Alzheimer's disease Neuroimaging Initiative were analyzed. We concentrated on the correlation between low frequency fMRI time courses in the FG and those in all other brain regions. Relative to the control group, we found some discrepant regions in the aMCI group which presented increased or decreased connectivity with the left/right FG including the left precuneus, left lingual gyrus, right thalamus, supramarginal gyrus, left supplementary motor area, left inferior temporal gyrus, and left parahippocampus. More importantly, we also obtained that both left and right FG have increased functional connections with the left middle occipital gyrus (MOG) and right anterior cingulate gyrus (ACC) in aMCI patients. That was not a coincidence and might imply that the MOG and ACC also play a critical role in visual cognition, especially face recognition. These findings in a large part supported our hypothesis and provided a new insight in understanding the important subtype of MCI.
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