ArticleFrontiers in human neuroscience2015
Adults with high social anhedonia have altered neural connectivity with ventral lateral prefrontal cortex when processing positive social signals.
Article in Frontiers in human neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Transdiagnostic Comparison of Anticipated Hedonic Deficits: A Three-Level Meta-Analysis Across Schizophrenia, Depression, and Their Subclinical Individuals.PsyCh journal · 2026Pooled it
- The causal role of the bilateral ventrolateral prefrontal cortices on emotion regulation of social feedback.Human brain mapping · 2022Trial
- The SocialVidStim: a video database of positive and negative social evaluation stimuli for use in social cognitive neuroscience paradigms.Social cognitive and affective neuroscience · 2024Article
- Cognitive Processes and Resting-State Functional Neuroimaging Findings in High Schizotypal Individuals and Schizotypal Personality Disorder Patients: A Systematic Review.Brain sciences · 2023Review
- Contributions of face processing, social anhedonia and mentalizing to the expression of social autistic-like traits.Frontiers in behavioral neuroscience · 2022Article
- Altered hippocampal-prefrontal functional network integrity in adult macaque monkeys with neonatal hippocampal lesions.NeuroImage · 2021Article
- Neural dynamics of monetary and social reward processing in social anhedonia.Social cognitive and affective neuroscience · 2020Article
- Reinforcement-Sensitive Personality Traits Associated With Passion in Heterosexual Intimate Relationships: An fNIRS Investigation.Frontiers in behavioral neuroscience · 2020Article
- Mapping anticipatory anhedonia: an fMRI study.Brain imaging and behavior · 2019Article
- Age-Associated Deviations of Amygdala Functional Connectivity in Youths With Psychosis Spectrum Disorders: Relevance to Psychotic Symptoms.The American journal of psychiatry · 2019Article
- A Transdiagnostic Perspective on Social Anhedonia.Frontiers in psychiatry · 2019Review
- Postnatal Administration of Dizocilpine Inhibits Neuronal Excitability in PFC and Induces Social Deficits Detected by MiceProfiler.Molecular neurobiology · 2017Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Social anhedonia (SA) is a debilitating characteristic of schizophrenia, a common feature in individuals at psychosis-risk, and a vulnerability for developing schizophrenia-spectrum disorders. Prior work (Hooker et al., 2014) revealed neural deficits in the ventral lateral prefrontal cortex (VLPFC) when processing positive social cues in a community sample of people with high SA. Lower VLPFC neural activity was related to more severe self-reported schizophrenia-spectrum symptoms as well as the exacerbation of symptoms after social stress. In the current study, psycho-physiological interaction (PPI) analysis was applied to further investigate the neural mechanisms mediated by the VLPFC during emotion processing. PPI analysis revealed that, compared to low SA controls, participants with high SA exhibited reduced connectivity between the VLPFC and the motor cortex, the inferior parietal and the posterior temporal regions when viewing socially positive (relative to neutral) emotions. Across all participants, VLPFC connectivity correlated with behavioral and self-reported measures of attentional control, emotion management, and reward processing. Our results suggest that impairments to the VLPFC mediated neural circuitry underlie the cognitive and emotional deficits associated with social anhedonia, and may serve as neural targets for prevention and treatment of schizophrenia-spectrum disorders.
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