ArticleFrontiers in behavioral neuroscience2015
Early adversity disrupts the adult use of aversive prediction errors to reduce fear in uncertainty.
Article in Frontiers in behavioral neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- Early caregiving adversity differentially shapes behavioral sensitivity to reward and risk during decision-making.Journal of experimental psychology. General · 2022Article
- A unidirectional but not uniform striatal landscape of dopamine signaling for motivational stimuli.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Retrorubral field is a hub for diverse threat and aversive outcome signals.Current biology : CB · 2021Article
- Foot shock facilitates reward seeking in an experience-dependent manner.Behavioural brain research · 2021Article
- Early adolescent adversity alters periaqueductal gray/dorsal raphe threat responding in adult female rats.Scientific reports · 2020Article
- Anterior Cingulate Cortex Signals Attention in a Social Paradigm that Manipulates Reward and Shock.Current biology : CB · 2020Article
- The Nucleus Accumbens Core is Necessary to Scale Fear to Degree of Threat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The ventrolateral periaqueductal grey updates fear via positive prediction error.The European journal of neuroscience · 2020Article
- Article
- Individual differences in voluntary alcohol consumption are associated with conditioned fear in the fear incubation model.Behavioural brain research · 2019Article
- Ventrolateral periaqueductal gray neurons prioritize threat probability over fear output.eLife · 2019Article
- Early adolescent adversity inflates threat estimation in females and promotes alcohol use initiation in both sexes.Behavioral neuroscience · 2018Article
- Inactivation of the Ventrolateral Orbitofrontal Cortex Impairs Flexible Use of Safety Signals.Neuroscience · 2018Article
- Lateral orbitofrontal cortex partitions mechanisms for fear regulation and alcohol consumption.PloS one · 2018Article
- Translational relevance of rodent models of hypothalamic-pituitary-adrenal function and stressors in adolescence.Neurobiology of stress · 2017Review
- Subsecond fear discrimination in rats: adult impairment in adolescent heavy alcohol drinkers.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Adolescent transitions in reflexive and non-reflexive behavior: Review of fear conditioning and impulse control in rodent models.Neuroscience and biobehavioral reviews · 2016Review
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
Early life adversity increases anxiety in adult rodents and primates, and increases the risk for developing post-traumatic disorder (PTSD) in humans. We hypothesized that early adversity impairs the use of learning signals -negative, aversive prediction errors-to reduce fear in uncertainty. To test this hypothesis, we gave adolescent rats a battery of adverse experiences then assessed adult performance in probabilistic Pavlovian fear conditioning and fear extinction. Rats were confronted with three cues associated with different probabilities of foot shock: one cue never predicted shock, another cue predicted shock with uncertainty, and a final cue always predicted shock. Control rats initially acquired fear to all cues, but rapidly reduced fear to the non-predictive and uncertain cues. Early adversity rats were slower to reduce fear to the non-predictive cue and never fully reduced fear to the uncertain cue. In extinction, all cues were presented in the absence of shock. Fear to the uncertain cue in discrimination, but not early adversity itself, predicted the reduction of fear in extinction. These results demonstrate early adversity impairs the use of negative aversive prediction errors to reduce fear, especially in situations of uncertainty.
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