ArticleJournal of inflammation (London, England)2015
RIG-I contributes to the innate immune response after cerebral ischemia.
Article in Journal of inflammation (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
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- The Sixth Sense: Self-nucleic acid sensing in the brain.Advances in immunology · 2024Review
- Article
- Secreted Extracellular Vesicle Molecular Cargo as a Novel Liquid Biopsy Diagnostics of Central Nervous System Diseases.International journal of molecular sciences · 2021Review
- Klotho deficiency intensifies hypoxia-induced expression of IFN-α/β through upregulation of RIG-I in kidneys.PloS one · 2021Article
- The RIG-I Signal Pathway MediatedEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Traumatic Brain Injury Induces cGAS Activation and Type I Interferon Signaling in Aged Mice.Frontiers in immunology · 2021Article
- Clonal diversity of the B cell receptor repertoire in patients with coronary in-stent restenosis and type 2 diabetes.Open life sciences · 2021Article
- Netosis and Inflammasomes in Large Vessel Occlusion Thrombi.Frontiers in pharmacology · 2020Article
- Pharmacological modulation of nucleic acid sensors - therapeutic potential and persisting obstacles.Nature reviews. Drug discovery · 2019Review
- Contribution of the inflammasome to inflammaging.Journal of inflammation (London, England) · 2018Article
- Inflammasome Proteins in Serum and Serum-Derived Extracellular Vesicles as Biomarkers of Stroke.Frontiers in molecular neuroscience · 2018Article
- Hypoxia triggers IFN-I production in muscle: Implications in dermatomyositis.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFocal cerebral ischemia induces an inflammatory response that when exacerbated contributes to deleterious outcomes. The molecular basis regarding the regulation of the innate immune response after focal cerebral ischemia remains poorly understood.
methodsIn this study we examined the expression of retinoic acid-inducible gene (RIG)-like receptor-I (RIG-I) and its involvement in regulating inflammation after ischemia in the brain of rats subjected to middle cerebral artery occlusion (MCAO). In addition, we studied the regulation of RIG-I after oxygen glucose deprivation (OGD) in astrocytes in culture.
resultsIn this study we show that in the hippocampus of rats, RIG-I and IFN-α are elevated after MCAO. Consistent with these results was an increased in RIG-I and IFN-α after OGD in astrocytes in culture. These data are consistent with immunohistochemical analysis of hippocampal sections, indicating that in GFAP-positive cells there was an increase in RIG-I after MCAO. In addition, in this study we have identified n-propyl gallate as an inhibitor of IFN-α signaling in astrocytes.
conclusionOur findings suggest a role for RIG-I in contributing to the innate immune response after focal cerebral ischemia.
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