Evidence map›Paper›PMID 26379416›Full record

ArticleEntropy (Basel, Switzerland)2011

Loop Entropy Assists Tertiary Order: Loopy Stabilization of Stacking Motifs.

Daniel P Aalberts

Open access · goldAbstract read
In one paragraph

Article in Entropy (Basel, Switzerland), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Daniel P AalbertsPhysics Department, Williams College, Williamstown, MA 01267, USA; Tel.: +1-413-597-3520;
Williams College · US

Funding

Binding and Splicing mRNAR15GM080690 · NIGMS · WILLIAMS COLLEGE · PI AALBERTS, DANIEL PAUL · 2007 to 2009
$300k
NIGMS NIH HHS R15 GM080690
6 · The paper itself

Abstract

The free energy of an RNA fold is a combination of favorable base pairing and stacking interactions competing with entropic costs of forming loops. Here we show how loop entropy, surprisingly, can promote tertiary order. A general formula for the free energy of forming multibranch and other RNA loops is derived with a polymer-physics based theory. We also derive a formula for the free energy of coaxial stacking in the context of a loop. Simulations support the analytic formulas. The effects of stacking of unpaired bases are also studied with simulations.

Indexed as

coaxial stackingHairpin loopsmultibranch loopspolymer simulationsRNAsecondary structuretertiary structure

Identifiers

PMID26379416
PMCPMC4569131
OpenAlexW2051274820

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.