Evidence map›Paper›PMID 26379335›Full record

ArticleSurface and interface analysis : SIA2014

Brain stem cell division and maintenance studied using multi-isotope imaging mass spectrometry (MIMS).

G Enikolopov, C Guillermier, M Wang, L Trakimas, M Steinhauser, C Lechene

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Surface and interface analysis : SIA, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Tracking cell turnover in human brain usingFrontiers in neuroscience · 2023
    Article
  2. Biological explorations with nanoscale secondary ion mass spectrometry.Journal of analytical atomic spectrometry · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

G EnikolopovCold Spring Harbor Laboratory, Cold Spring Harbor, NY USA.
C GuillermierDivision of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA USA ; National Resource for Imaging Mass Spectrometry (NRIMS), Cambridge, MA USA.
M WangNational Resource for Imaging Mass Spectrometry (NRIMS), Cambridge, MA USA.
L TrakimasDepartment of Cell Biology, Harvard Medical School, Boston, MA USA.
M SteinhauserDivision of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA USA ; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA USA.
C LecheneDivision of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA USA ; National Resource for Imaging Mass Spectrometry (NRIMS), Cambridge, MA USA.
Brigham and Women's Hospital · USHarvard University · USCold Spring Harbor Laboratory · US

Funding

National Resources for Imaging Mass SpectrometryP41EB001974 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI LECHENE, CLAUDE P · 2004 to 2014
$11.8M
Neural stem cells in the aging brainR01AG040209 · NIA · STATE UNIVERSITY NEW YORK STONY BROOK · PI ENIKOLOPOV, GRIGORI N · 2011 to 2015
$2.1M
NanoSIMS 50L Ion Micro-AnalyzerS10RR025116 · NCRR · BRIGHAM AND WOMEN'S HOSPITAL · PI LECHENE, CLAUDE P · 2008 to 2008
$2.0M
Cardiomyocyte Lineage and Turnover by Metabolic Fate-MappingR01AG040019 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI LEE, RICHARD T · 2011 to 2015
$1.9M
Stable isotope-based fate mapping to quantify adipogenesis in obesityK08DK090147 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI STEINHAUSER, MATTHEW · 2012 to 2016
$801k
National Resource for Imaging Mass SpectrometryP20EB001974 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI LECHENE, CLAUDE P · 2003 to 2003
$727k
Cell fate and tissue turnover in the aged studied with multi-isotope imaging massR21AG034641 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI LECHENE, CLAUDE P · 2009 to 2010
$489k
NCRR NIH HHS S10 RR025116NIA NIH HHS R01 AG040019NIA NIH HHS R01 AG040209NIA NIH HHS R21 AG034641NIBIB NIH HHS P20 EB001974NIBIB NIH HHS P41 EB001974NIDDK NIH HHS K08 DK090147
6 · The paper itself

Abstract

New neurons are continuously produced from neural stem cells in specific regions of the adult brain of animals and humans. In the hippocampus, a region crucial for cognitive function, neurogenesis responds to a multitude of extrinsic stimuli; emerging evidence indicates that it may be important for behavior, pathophysiology, brain repair, and response to drugs. We have developed an approach to identify and quantify the cellular targets of pro- and anti-neurogenic stimuli, based on reporter transgenic mouse lines in which neural stem and progenitor cells or their progeny are marked by fluorescent proteins. Here, we demonstrate the feasibility of using MIMS for studying adult neurogenesis.

Indexed as

HippocampusMIMSMulti-isotope Imaging Mass SpectrometryStem cell division

Identifiers

PMID26379335
PMCPMC4566142
OpenAlexW2136935086

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.