ArticlePloS one2015
No Major Host Genetic Risk Factor Contributed to A(H1N1)2009 Influenza Severity.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Investigating the Impact of Host Genetics on the Risk of Disease Progression in Individuals With Influenza.Immunity, inflammation and disease · 2026Article
- Interferon-stimulated gene GALNT2 restricts respiratory virus infections.Nature microbiology · 2026Article
- Genetic risk factors for COVID-19 and influenza are largely distinct.Nature genetics · 2024Article
- Scalable genetic screening for regulatory circuits using compressed Perturb-seq.Nature biotechnology · 2024Article
- Identification of Causal Relationships between Gut Microbiota and Influenza a Virus Infection in Chinese by Mendelian Randomization.Microorganisms · 2024Article
- Single-cell genome-wide association reveals that a nonsynonymous variant inCell genomics · 2022Article
- Genetic Predisposition and the Variable Course of Infectious Diseases.Deutsches Arzteblatt international · 2022Review
- A host-based whole genome sequencing study reveals novel risk loci associated with severity of influenza A(H1N1)pdm09 infection.Emerging microbes & infections · 2021Article
- Genetic architecture of type 1 diabetes with low genetic risk score informed by 41 unreported loci.Communications biology · 2021Article
- Genome-wide association study of susceptibility to hospitalised respiratory infections.Wellcome open research · 2021Article
- Role of the ADCY9 gene in cardiac abnormalities of the Rubinstein-Taybi syndrome.Orphanet journal of rare diseases · 2020Article
- Identification of complement-related host genetic risk factors associated with influenza A(H1N1)pdm09 outcome: challenges ahead.Medical microbiology and immunology · 2019Article
- IFITM3: How genetics influence influenza infection demographically.Biomedical journal · 2019Review
- Genetic susceptibility to infectious diseases: Current status and future perspectives from genome-wide approaches.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2018Review
- IFITM3, TLR3, and CD55 Gene SNPs and Cumulative Genetic Risks for Severe Outcomes in Chinese Patients With H7N9/H1N1pdm09 Influenza.The Journal of infectious diseases · 2017Article
- Correction: No Major Host Genetic Risk Factor Contributed to A(H1N1)2009 Influenza Severity.PloS one · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
14 authors at 10 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While most patients affected by the influenza A(H1N1) pandemic experienced mild symptoms, a small fraction required hospitalization, often without concomitant factors that could explain such a severe course. We hypothesize that host genetic factors could contribute to aggravate the disease. To test this hypothesis, we compared the allele frequencies of 547,296 genome-wide single nucleotide polymorphisms (SNPs) between 49 severe and 107 mild confirmed influenza A cases, as well as against a general population sample of 549 individuals. When comparing severe vs. mild influenza A cases, only one SNP was close to the conventional p = 5×10-8. This SNP, rs28454025, sits in an intron of the GSK233 gene, which is involved in a neural development, but seems not to have any connections with immunological or inflammatory functions. Indirectly, a previous association reported with CD55 was replicated. Although sample sizes are low, we show that the statistical power in our design was sufficient to detect highly-penetrant, quasi-Mendelian genetic factors. Hence, and assuming that rs28454025 is likely to be a false positive, no major genetic factor was detected that could explain poor influenza A course.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.