Evidence map›Paper›PMID 26378794›Full record

SynthesisPloS one2015

Effects of Combined Aerobic and Resistance Exercise on Exercise Capacity, Muscle Strength and Quality of Life in HIV-Infected Patients: A Systematic Review and Meta-Analysis.

Mansueto Gomes Neto, Cristiano Sena Conceição, Vitor Oliveira Carvalho, Carlos Brites

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03075332 (Detraining in the Components of Physical Aptitude in People Living With HIV/ AIDS), which is not on this map. Cited by 42 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 7 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03075332 nacompletednot on this mapstarted 2016, after this paper: background citation

Detraining in the Components of Physical Aptitude in People Living With HIV/ AIDS

TypeinterventionalSponsorUniversidade Federal do Rio Grande do NorteRan2016 to 2016Enrolled2ConditionsLipodystrophy Syndrome, HIV, SarcopeniaArmscombined training
3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 7 syntheses or guidelines pooled it, 80 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Mansueto Gomes NetoDepartamento de Biofunçāo, Curso de Fisioterapia da Universidade Federal da Bahia, UFBA, Salvador, BA, Brazil; Programa de Pós Graduação em Medicina e Saúde, UFBA, Salvador, BA, Brazil; The GREAT Group (GRupo de Estudos em ATividade física), Universidade Federal de Sergipe, Aracaju, SE, Brazil.
Cristiano Sena ConceiçãoDepartamento de Biofunçāo, Curso de Fisioterapia da Universidade Federal da Bahia, UFBA, Salvador, BA, Brazil.
Vitor Oliveira CarvalhoThe GREAT Group (GRupo de Estudos em ATividade física), Universidade Federal de Sergipe, Aracaju, SE, Brazil; Departamento de Fisioterapia da Universidade Federal de Sergipe, UFS, Aracaju, SE, Brazil.
Carlos BritesPrograma de Pós Graduação em Medicina e Saúde, UFBA, Salvador, BA, Brazil.
Universidade Federal da Bahia · BRUniversidade Federal de Sergipe · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMany HIV-infected patients demonstrate disability and lower aerobic capacity. The inclusion of resistance training combined with aerobic exercise in a single program is known as combined aerobic and resistance exercise (CARE) and seems to be an effective strategy to improve muscle weakness, as well as aerobic capacity in HIV-infected patients. We performed a meta-analysis to investigate the effects of CARE in HIV-infected patients.

methodsWe searched MEDLINE, Cochrane Controlled Trials Register, EMBASE, CINAHL (from the earliest date available to august 2014) for controlled trials that evaluated the effects of CARE in HIV-infected patients. Weighted mean differences (WMD) and 95% confidence intervals (CIs) were calculated, and heterogeneity was assessed using the I2 test.

resultsSeven studies met the study criteria. CARE resulted in improvement in Peak VO2 WMD (4.48 mL·kg-1·min-1 95% CI: 2.95 to 6.0), muscle strength of the knee extensors WMD (25.06 Kg 95% CI: 10.46 to 39.66) and elbow flexors WMD (4.44 Kg 95% CI: 1.22 to 7.67) compared with no exercise group. The meta-analyses also showed significant improvement in Health status, Energy/Vitality and physical function domains of quality of life for participants in the CARE group compared with no exercise group. A nonsignificant improvement in social function domain of quality of life was found for participants in the CARE group compared with no exercise group.

conclusionsCombined aerobic and resistance exercise may improve peak VO2, muscle strength and health status, energy and physical function domains of quality of life and should be considered as a component of care of HIV-infected individuals.

Indexed as

AdultExerciseExercise TherapyExercise ToleranceFemaleHealth StatusHIV InfectionsHumansMaleMiddle AgedMuscle StrengthOxygenQuality of LifeResistance TrainingOxygen

Identifiers

PMID26378794
PMCPMC4574781
OpenAlexW2173758656

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.