ReviewGenes2015
Replication Stress: A Lifetime of Epigenetic Change.
Review in Genes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
- Architectural fragility of gene regulatory networks underlies hematopoietic stem cell aging.bioRxiv : the preprint server for biology · 2026Article
- CTCF/cohesin-binding sites are susceptible to replication-associated DNA damage and genomic instability in cancer cells.iScience · 2026Article
- Replication stress: an early key event in ochratoxin a genotoxicity?Archives of toxicology · 2025Article
- A multi-omics Mendelian randomization study identifies new therapeutic targets for alcohol use disorder and problem drinking.Nature human behaviour · 2025Article
- Transcription as source of genetic heterogeneity in budding yeast.Yeast (Chichester, England) · 2024Review
- DELVE: feature selection for preserving biological trajectories in single-cell data.Nature communications · 2024Article
- Article
- Feature selection for preserving biological trajectories in single-cell data.bioRxiv : the preprint server for biology · 2023Article
- Article
- Inducible SMARCAL1 knockdown in iPSC reveals a link between replication stress and altered expression of master differentiation genes.Disease models & mechanisms · 2019Article
- Epigenetic Changes as a Target in Aging Haematopoietic Stem Cells and Age-Related Malignancies.Cells · 2019Review
- Destabilization of chromosome structure by histone H3 lysine 27 methylation.PLoS genetics · 2019Article
- JNK-dependent cell cycle stalling in G2 promotes survival and senescence-like phenotypes in tissue stress.eLife · 2019Article
- Review
- Chromatin architecture changes and DNA replication fork collapse are critical features in cryopreserved cells that are differentially controlled by cryoprotectants.Scientific reports · 2018Article
- MOF Suppresses Replication Stress and Contributes to Resolution of Stalled Replication Forks.Molecular and cellular biology · 2018Article
- Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions.Molecular cell · 2018Article
- The histone variant macroH2A1 is a splicing-modulated caretaker of genome integrity and tumor growth.Molecular & cellular oncology · 2018Article
- Transcription-associated events affecting genomic integrity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Functional Mechanisms of Microsatellite DNA in Eukaryotic Genomes.Genome biology and evolution · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
DNA replication is essential for cell division. Challenges to the progression of DNA polymerase can result in replication stress, promoting the stalling and ultimately collapse of replication forks. The latter involves the formation of DNA double-strand breaks (DSBs) and has been linked to both genome instability and irreversible cell cycle arrest (senescence). Recent technological advances have elucidated many of the factors that contribute to the sensing and repair of stalled or broken replication forks. In addition to bona fide repair factors, these efforts highlight a range of chromatin-associated changes at and near sites of replication stress, suggesting defects in epigenome maintenance as a potential outcome of aberrant DNA replication. Here, we will summarize recent insight into replication stress-induced chromatin-reorganization and will speculate on possible adverse effects for gene expression, nuclear integrity and, ultimately, cell function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.