Evidence map›Paper›PMID 26378496›Full record

ReviewThe Analyst2016

Detection and isolation of circulating exosomes and microvesicles for cancer monitoring and diagnostics using micro-/nano-based devices.

Jina Ko, Erica Carpenter, David Issadore

Abstract readReview
In one paragraph

Review in The Analyst, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed.

  1. Article
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  6. Article
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  9. Review
  10. Extracellular Vesicles as Source of Biomarkers in Glomerulonephritis.International journal of molecular sciences · 2023
    Review
  11. Article
  12. Impact of exosome therapy on pancreatic cancer and its progression.Medical oncology (Northwood, London, England) · 2023
    Review
  13. Review
  14. Review
  15. Article
  16. Article
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  19. Article
  20. Review

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jina KoDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Erica Carpenter *Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
David Issadore *Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ROBERT GROSS · 1999 to 2026
$78.6M
A micro Hall chip for circulating microvesicle based cancer monitoringR21CA182336 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ISSADORE, DAVID AARON · 2014 to 2016
$664k
NCI NIH HHS R21 CA182336NIAID NIH HHS P30 AI045008
6 · The paper itself

Abstract

In the last several years, nanoscale vesicles that originate from tumor cells and which can be found circulating in the blood (i.e. exosomes and microvesicles) have been discovered to contain a wealth of proteomic and genetic information to monitor cancer progression, metastasis, and drug efficacy. However, the use of exosomes and microvesicles as biomarkers to improve patient care has been limited by their small size (30 nm-1 μm) and the extensive sample preparation required for their isolation and measurement. In this Critical Review, we explore the emerging use of micro and nano-technology to isolate and detect exosomes and microvesicles in clinical samples and the application of this technology to the monitoring and diagnosis of cancer.

Indexed as

AnimalsExosomesHumansMicrotechnologyNanotechnologyNeoplasms

Identifiers

PMID26378496
PMCPMC4881422

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.