Evidence map›Paper›PMID 26378135›Full record

ArticleJournal of analytical toxicology2015

Analysis of 25I-NBOMe, 25B-NBOMe, 25C-NBOMe and Other Dimethoxyphenyl-N-[(2-Methoxyphenyl) Methyl]Ethanamine Derivatives on Blotter Paper.

Justin L Poklis, Stephen A Raso, Kylie N Alford, Alphonse Poklis, Michelle R Peace

Abstract read
In one paragraph

Article in Journal of analytical toxicology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Applications of DESI and DART Mass Spectrometry in Forensic Science.Journal of the American Society for Mass Spectrometry · 2025
    Review
  2. Applications of MALDI mass spectrometry in forensic science.Analytical and bioanalytical chemistry · 2024
    Review
  3. Molecular and Medical Aspects of Psychedelics.International journal of molecular sciences · 2023
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Forensic applications of DART-MS: A review of recent literature.Forensic chemistry (Amsterdam, Netherlands) · 2021
    Article
  11. Article
  12. Article
  13. DARK Classics in Chemical Neuroscience: NBOMes.ACS chemical neuroscience · 2020
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Justin L PoklisDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.
Stephen A RasoDepartment of Forensic Science, Virginia Commonwealth University, PO Box 843079, 1015 Floyd Avenue, Room 2015, Richmond 23284, VA, USA.
Kylie N AlfordDepartment of Forensic Science, Virginia Commonwealth University, PO Box 843079, 1015 Floyd Avenue, Room 2015, Richmond 23284, VA, USA.
Alphonse PoklisDepartment of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA Department of Forensic Science, Virginia Commonwealth University, PO Box 843079, 1015 Floyd Avenue, Room 2015, Richmond 23284, VA, USA Department of Pathology, Virginia Commonwealth University, Richmond, VA, USA.
Michelle R PeaceDepartment of Forensic Science, Virginia Commonwealth University, PO Box 843079, 1015 Floyd Avenue, Room 2015, Richmond 23284, VA, USA mrpeace@vcu.edu.

Funding

VCU Center for Drug Addiction ResearchP30DA033934 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI Matthew Sean Halquist · 2014 to 2026
$13.8M
NIDA NIH HHS P30 DA033934NIDA NIH HHS P30DA033934
6 · The paper itself

Abstract

In recent years, N-methoxybenzyl-methoxyphenylethylamine (NBOMe) derivatives, a class of designer hallucinogenic drugs, have become popular drugs of abuse. These drugs have been the cause of severe intoxications and even deaths. They act as 5-HT2A receptors agonists and have been reported to produce serotonin-like syndrome with bizarre behavior, severe agitation and seizures persisting for as long as 3 days. The most commonly reported derivatives are 25I-NBOMe, 25B-NBOMe and 25C-NBOMe, respectively 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl) methyl]ethanamine, N-(2-methoxybenzyl)-2,5-dimethoxy-4-bromophenethylamine and N-(2-methoxybenzyl)-2,5-dimethoxy-4-chlorophenethylamine. Like many low dose hallucinogenic drugs these compounds are often sold on blotter paper. Three different types of commercially available blotter papers reported to contain NBOMe derivatives were obtained. These blotter papers were screened using Direct Analysis in Real Time AccuTOF(TM) mass spectrometry followed by confirmation and quantification by high-performance liquid chromatography triple quadrapole mass spectrometry. The major drug present on each of the three blotter products was different, 25I-NBOMe, 25C-NBOMe or 25B-NBOMe. The blotter papers were also found to have minute amounts of two or three NBOMe derivative impurities of 25H-NBOMe, 25I-NBOMe, 25C-NBOMe, 25B-NBOMe and/or 25D-NBOMe.

Indexed as

AnisolesBenzylaminesChromatography, High Pressure LiquidDimethoxyphenylethylaminePhenethylaminesTandem Mass Spectrometry2-(4-bromo-2,5-dimethoxyphenyl)-N-((2-methoxyphenyl)methyl)ethanamine2-(4-chloro-2,5-dimethoxyphenyl)-N-((2-methoxyphenyl)methyl)ethanamine2-(4-iodo-2,5-dimethoxyphenyl)-N-(2-methoxybenzyl)ethanamineAnisolesBenzylaminesDimethoxyphenylethylaminePhenethylamines

Identifiers

PMID26378135
PMCPMC4570937

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.