Evidence map›Paper›PMID 26378022›Full record

ArticleOncotarget2015

Golgi protein 73 activation of MMP-13 promotes hepatocellular carcinoma cell invasion.

Di Jin, Jun Tao, Dan Li, Yanan Wang, Li Li, Zhongdong Hu, Zhenzhen Zhou, Xiuli Chang, Chunfeng Qu, Hongbing Zhang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 51 citations in OpenAlex.

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  19. Research progress on GP73 in malignant tumors.OncoTargets and therapy · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Di JinInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
Jun TaoState Key Laboratory of Medical Molecular Biology, Department of Physiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Dan LiCell Engineering Research Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Yanan WangState Key Laboratory of Medical Molecular Biology, Department of Physiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Li LiState Key Laboratory of Medical Molecular Biology, Department of Physiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhongdong HuModern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Zhenzhen ZhouDepartment of Physiology, Dalian Medical University, Dalian, China.
Xiuli ChangState Key Laboratory of Molecular Oncology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Chunfeng QuState Key Laboratory of Molecular Oncology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Hongbing ZhangInstitute of Cancer Stem Cell, Dalian Medical University, Dalian, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNDalian Medical University · CNBeijing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Golgi Protein 73 (GP73) is a serum biomarker for hepatocellular carcinoma (HCC), however its role in HCC is not clear. We report that GP73 promotes cell invasion, the hallmark of malignancy, through the upregulation of matrix metalloproteinase-13 (MMP-13). GP73 enhances MMP-13 expression through cAMP responsive element binding protein (CREB)-mediated transcription activation. Levels of GP73 and MMP-13 are increased and positively correlated in human HCC tissues. Augmented MMP-13 potentiates HCC cell metastasis. Thus, the GP73-CREB-MMP-13 axis potentiates cancer cell invasion and may be a target for HCC treatment.

Indexed as

Carcinoma, HepatocellularCell Line, TumorCyclic AMP Response Element-Binding ProteinHep G2 CellsHumansLiver NeoplasmsMatrix Metalloproteinase 13Membrane ProteinsNeoplasm InvasivenessCREB1 protein, humanCyclic AMP Response Element-Binding ProteinGOLM1 protein, humanMatrix Metalloproteinase 13Membrane ProteinsMMP13 protein, humanGP73hepatocellular carcinomainvasionmatrix metalloproteinase-13

Identifiers

PMID26378022
PMCPMC4741783
OpenAlexW2267660831

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.