Evidence map›Paper›PMID 26377947›Full record

ReviewCurrent psychiatry reports2015

Premenstrual Dysphoric Disorder: Epidemiology and Treatment.

Liisa Hantsoo, C Neill Epperson

Registry-linked trialAbstract readReview
In one paragraph

Review in Current psychiatry reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02777372 (Psychophysiology, Neurosteroids, and Stress in Premenstrual Dysphoric Disorder), which is not on this map. Cited by 137 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
137citing papers in PubMed, 8 pooled it
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02777372 phase4completednot on this mapstarted 2016, after this paper: background citation

Psychophysiology, Neurosteroids, and Stress in Premenstrual Dysphoric Disorder

TypeinterventionalSponsorJohns Hopkins UniversityRan2016 to 2021Enrolled84ConditionsPMDD, Stress, MoodArmsSertraline
3 · Its place in the literature

Who cites it

137 citing papers in PubMed, 8 syntheses or guidelines pooled it, 309 citations in OpenAlex.

  1. Pooled it
  2. ADHD and Sex Hormones in Females: A Systematic Review.Journal of attention disorders · 2025
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77 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Liisa HantsooDepartment of Psychiatry, Penn Center for Women's Behavioral Wellness, 3535 Market Street, 3rd Floor, Philadelphia, PA, 19104, USA. liisaha2@mail.med.upenn.edu.
C Neill EppersonDepartment of Psychiatry, Penn Center for Women's Behavioral Wellness, 3535 Market Street, 3rd Floor, Philadelphia, PA, 19104, USA. cepp@mail.med.upenn.edu.
University of Pennsylvania · US

Funding

Prepubertal Stress, Windows of Risk & Sex Bias for Affective DisturbanceP50MH099910 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI KIM, DEBORAH · 2012 to 2017
$6.5M
Neuroendocrine Contribution to Behavior & Cognition in the Female LifespanK24DA030301 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI EPPERSON, C. NEILL · 2010 to 2014
$954k
NIDA NIH HHS K24 DA030301NIMH NIH HHS P50 MH099910
6 · The paper itself

Abstract

Recently designated as a disorder in the DSM-5, premenstrual dysphoric disorder (PMDD) presents an array of avenues for further research. PMDD's profile, characterized by cognitive-affective symptoms during the premenstruum, is unique from that of other affective disorders in its symptoms and cyclicity. Neurosteroids may be a key contributor to PMDD's clinical presentation and etiology, and represent a potential avenue for drug development. This review will present recent literature on potential contributors to PMDD's pathophysiology, including neurosteroids and stress, and explore potential treatment targets.

Indexed as

Premenstrual Dysphoric DisorderDiagnosis, DifferentialDiagnostic and Statistical Manual of Mental DisordersDisease ManagementFemalegamma-Aminobutyric AcidHumansMood DisordersPremenstrual Syndromegamma-Aminobutyric AcidGABAMenstrual cyclePMDDPMSPremenstrual

Identifiers

PMID26377947
PMCPMC4890701
OpenAlexW2107799638

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.