Evidence map›Paper›PMID 26377838›Full record

ArticleExpert review of pharmacoeconomics & outcomes research2015

Long-term costs of introducing HPV-DNA post-treatment surveillance to national cervical cancer screening in Ireland.

Maria Agapova, Andrea Duignan, Alan Smith, Ciaran O'Neill, Anirban Basu

Abstract read
In one paragraph

Article in Expert review of pharmacoeconomics & outcomes research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maria Agapovaa 1 Pharmaceutical Outcomes Research and Policy Program (PORPP), University of Washington, Seattle, USA.
Andrea Duignanb 2 National Cancer Screening Service, Dublin, Ireland.
Alan Smithb 2 National Cancer Screening Service, Dublin, Ireland.
Ciaran O'Neillc 3 School of Business and Economics, National University of Ireland, Galway, Ireland.
Anirban Basua 1 Pharmaceutical Outcomes Research and Policy Program (PORPP), University of Washington, Seattle, USA.

Funding

Advancing Instrumental Variable Methods in Comparative Effectiveness ResearchRC4CA155809 · NCI · UNIVERSITY OF WASHINGTON · PI BASU, ANIRBAN · 2010 to 2010
$1.5M
Instrumental Variable Methods for Censored Cost Data and an Application in ProstaR01CA155329 · NCI · UNIVERSITY OF WASHINGTON · PI BASU, ANIRBAN · 2011 to 2013
$1.3M
NCI NIH HHS R01CA15532NCI NIH HHS R01 CA155329NCI NIH HHS RC4CA15580NCI NIH HHS RC4 CA155809
6 · The paper itself

Abstract

introductionCo-testing (cytology plus human papillomavirus DNA testing) as part of cervical cancer surveillance in Ireland increases one-time testing costs. Of interest to policy makers was the long-term impact of these costs accompanied by decreases in intensity of recalls for women with no detected abnormalities.

methodsA cost analysis of cytology-only and co-testing strategy was implemented using decision analytic modeling, aggregating testing utilization and costs for each of the two strategies over 12 years.

resultsAggregated incremental costs of the co-testing strategy were positive for the first 3 years but became negative thereafter, generating a cost savings of roughly €20 million in favor of the cytology-only strategy over a 12-year period. Results were robust over a range of sensitivity analyses with respect to discount and attrition rates. DISCUSSION: This analysis provided valuable information to policy makers contributing to the introduction of co-testing for post-treatment surveillance (PTS) in Ireland.

Indexed as

AdultCost SavingsDecision Support TechniquesDNA, ViralFemaleHumansIrelandMass ScreeningMiddle AgedPapillomaviridaePapillomavirus InfectionsSensitivity and SpecificityTime FactorsUterine Cervical NeoplasmsDNA, Viralcervical cancercolposcopycosts analysisdecision analysishuman papillomaviruspost-treatment surveillancescreening

Identifiers

PMID26377838
PMCPMC5902188

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.