Trial reportRadiation oncology (London, England)2015
Determining appropriate timing of adaptive radiation therapy for nasopharyngeal carcinoma during intensity-modulated radiation therapy.
Trial report in Radiation oncology (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Trial
- Predicting the benefit of adaptive radiotherapy in head and neck Cancer using cone-beam computed tomography.Physics and imaging in radiation oncology · 2026Article
- Synthetic CT-enabled weekly adaptive radiotherapy for nasopharyngeal carcinoma: Optimizing plan adaptation triggers through volumetric-dosimetric monitoring.Journal of applied clinical medical physics · 2026Article
- Assessment of the optimal timing for projected dose evaluation in head and neck cancer patients treated with helical tomotherapy.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2026Article
- A subgroup analysis of locally advanced nasopharyngeal carcinoma patients with small lymph nodes and large nodes using adaptive radiotherapy.BMC cancer · 2025Article
- Nasopharyngeal cancer adaptive radiotherapy with CBCT-derived synthetic CT: deep learning-based auto-segmentation precision and dose calculation consistency on a C-Arm linac.Radiation oncology (London, England) · 2025Article
- Investigating the necessity of adaptive radiotherapy in tomotherapy of head and neck cancer patients.Radiation oncology (London, England) · 2025Article
- Verification of daily dose recalculation accuracy for an adaptive radiation therapy monitoring tool in helical tomotherapy for nasopharyngeal carcinoma.Journal of applied clinical medical physics · 2025Article
- Adaptive radiotherapy in locally advanced head and neck cancer: The importance of reduced margins.Physics and imaging in radiation oncology · 2025Article
- Anatomical and dosimetric variations during volumetric modulated arc therapy in patients with locally advanced nasopharyngeal carcinoma after induction therapy: Implications for adaptive radiation therapy.Clinical and translational radiation oncology · 2024Article
- A multicenter dataset for lymph node clinical target volume delineation of nasopharyngeal carcinoma.Scientific data · 2024Article
- Adaptive radiotherapy for head and neck cancer: Pitfalls and possibilities from the radiation oncologist's point of view.Cancer medicine · 2024Review
- Review
- Triggering daily online adaptive radiotherapy in the pelvis: Dosimetric effects and procedural implications of trigger parameter-value selection.Journal of applied clinical medical physics · 2023Article
- Potential benefits of adaptive intensity-modulated proton therapy in nasopharyngeal carcinomas.Journal of applied clinical medical physics · 2021Article
- Adaptive radiotherapy for head and neck cancer.Cancers of the head & neck · 2020Review
- Adaptive radiotherapy for head and neck cancer reduces the requirement for rescans during treatment due to spinal cord dose.Radiation oncology (London, England) · 2019Article
- Framework for the quantitative assessment of adaptive radiation therapy protocols.Journal of applied clinical medical physics · 2018Article
- Three-Phase Adaptive Radiation Therapy for Patients With Nasopharyngeal Carcinoma Undergoing Intensity-Modulated Radiation Therapy: Dosimetric Analysis.Technology in cancer research & treatment · 2017Article
- Potential proton and photon dose degradation in advanced head and neck cancer patients by intratherapy changes.Journal of applied clinical medical physics · 2017Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo determine appropriate timing of an adaptive radiation therapy (ART) replan by evaluating anatomic and dosimetric changes of target volumes and organs at risk (OARs) during intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma (NPC).
methodsNineteen NPC patients were recruited. Each patient had repeat computed tomography (CT) scans after each five fractions and at treatment completion. Automatic re-contouring the targets and OARs by using deformable registration algorithm was conducted through CT-CT fusion. Anatomic changes were assessed by comparing the initial CT and repeated CT. Hybrid plans with re-contouring were generated and the dose-volume histograms (DVH) of the hybrid plan and the original plan were compared.
resultsProgressive volume reductions in gross target volume for primary disease (GTVnx), gross target volume for involved lymph nodes (GTVnd), and parotids were observed over time. Comparing with the original plan, each hybrid plan had no significant difference in homogeneity index (HI) for all the targets. Some parameters for planning target volumes for primary disease and high-risk clinical target volume (PTVnx and PTV1, respectively) improved significantly, notably starting from the 10th fraction. These parameters included mean dose (Dmean), dose to 95% of the volume (D95), percentage of the volume receiving 95% of the prescription dose (V95), and conformity index (CI) for PTVnx, and Dmean, D95, and CI for PTV1. The dosimetric parameters for PTVnd remained the same in general except for D95 and V95 which had significant improvement at specific time points; whereas for PTV2, similar trend of dosimetric changes was also observed. Dose to some OARs increased significantly at some time points.
conclusionsThere were significant anatomic and dosimetric changes in the targets and OARs. The target dose coverage in the hybrid plans did not get worse, but overdose occurred in some critical structures. Significant dosimetric changes should be considered as a trigger point at which ART replanning is indicated. D95/V95/CI for PTV2, Dmax for the brain stem, spinal cord, right eyeball and left lens, and Dmean/V30 for the parotids and glottis were taken into account for predicting the need for ART. Two replans at the 5th and 15th fractions were suggested.
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